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Serum matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in esophageal cancer patients
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Abstract
correlated with cancer stage and clinico-pathological features of tumor and patients’ survival. However, little is
known about serum levels of those proteins in EC patients. The aim of the present study was to investigate the
diagnostic significance of MMP-2 and TIMP-2 serum levels in EC patients in relation to clinico-pathological
features of cancer. The study included 53 EC patients and 92 healthy controls. The serum levels of MMP-2,
TIMP-2 and classical tumor markers CEA (carcinoembryonic antigen) and SCC (squamous cell carcinoma
antigen) were assayed. The prognostic values and diagnostic criteria for the biomarkers tested were defined.
Serum levels of MMP-2, TIMP-2 in EC patients were significantly lower, whereas CEA and SCC significantly
higher than in control group. The diagnostic sensitivity of TIMP-2 (57%) was higher than those for other biomarkers
tested and increased in combination with SCC (70%). Area under ROC curve for TIMP-2 (0.8698) was
larger than for other proteins. In Cox’s univariate analysis only SCC serum levels were significant prognostic
factors for EC patients’ survival. The results suggest the limited value of serum analyses of MMP-2 for tumor
staging and prognosis in EC and the better usefulness of TIMP-2 than MMP-2 as a tumor marker in the diagnosis
of EC, especially in combined use with SCC.
Abstract
correlated with cancer stage and clinico-pathological features of tumor and patients’ survival. However, little is
known about serum levels of those proteins in EC patients. The aim of the present study was to investigate the
diagnostic significance of MMP-2 and TIMP-2 serum levels in EC patients in relation to clinico-pathological
features of cancer. The study included 53 EC patients and 92 healthy controls. The serum levels of MMP-2,
TIMP-2 and classical tumor markers CEA (carcinoembryonic antigen) and SCC (squamous cell carcinoma
antigen) were assayed. The prognostic values and diagnostic criteria for the biomarkers tested were defined.
Serum levels of MMP-2, TIMP-2 in EC patients were significantly lower, whereas CEA and SCC significantly
higher than in control group. The diagnostic sensitivity of TIMP-2 (57%) was higher than those for other biomarkers
tested and increased in combination with SCC (70%). Area under ROC curve for TIMP-2 (0.8698) was
larger than for other proteins. In Cox’s univariate analysis only SCC serum levels were significant prognostic
factors for EC patients’ survival. The results suggest the limited value of serum analyses of MMP-2 for tumor
staging and prognosis in EC and the better usefulness of TIMP-2 than MMP-2 as a tumor marker in the diagnosis
of EC, especially in combined use with SCC.
About this articleTitle
Serum matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in esophageal cancer patients
Journal
Folia Histochemica et Cytobiologica
Issue
Article type
Original paper
Pages
590-598
Published online
2012-12-23
Page views
1680
Article views/downloads
2760
DOI
10.5603/FHC.2012.0083
Bibliographic record
Folia Histochem Cytobiol 2012;50(4):590-598.
Authors
Magdalena Groblewska
Barbara Mroczko
Miroslaw Kozlowski
Jacek Niklinski
Jerzy Laudanski
Maciej Szmitkowski
