Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011, 155(4):347-353 | DOI: 10.5507/bp.2011.050

INFLUENCE OF AGE AND GENDER ON THE PHARMACODYNAMIC PARAMETERS OF ROCURONIUM DURING TOTAL INTRAVENOUS ANESTHESIA

Milan Adamusa, Lumir Hrabalekb, Tomas Wanekb, Tomas Gabrhelika, Jana Zapletalovac,d
a Department of Anesthesiology and Intensive Care Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic
b Department of Neurosurgery, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc
c Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc
d Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc

Aims: To compare the pharmacodynamics of 0.6 mg kg-1 rocuronium in young and older patients of both genders during total intravenous anesthesia.

Methods: Following local ethics committee approval and informed consent, patients scheduled for surgery under total intravenous anesthesia (propofol/sufentanil) were divided into 4 study groups: 37 males aged 20-40, 40 males aged 60-75 yrs, 43 females aged 20-40 and 38 females aged 60-75 yrs. Neuromuscular block following rocuronium (0.6 mg kg-1) was monitored: train-of-four [TOF] stimulation of the ulnar nerve at 15-s intervals, EMG of the adductor pollicis muscle. The onset time (from application of rocuronium to maximum depression of T1), clinical duration (from application to 25% recovery of T1), and time to full spontaneous recovery (from application to TOF-ratio ≥ 0.9) were determined for each patient. The Kruskal-Wallis test was used to compare differences between groups; P<0.05 was considered statistically significant.

Results: The onset time (median [interquartile range]) in the respective groups was 90 [80-110]BCD, 135 [116-165]AC, 75 [60-90]ABD, and 120 [90-146]AC seconds. The clinical duration was 30 [25-42]BCD, 58 [53-67]AD, 50 [40-65]AD, and 85 [70-90]ABC min. Interval to full spontaneous recovery was 59 [51-67]BCD, 102 [75-106]A, 76 [66-91]AD, and 128 [94-137]AC min. (AP<0.05 vs. young males, BP<0.05 vs. elderly males, CP<0.05 vs. young females, DP<0.05 vs. elderly females).

Conclusion: Females and older patients were more sensitive to rocuronium.

Keywords: Rocuronium, Neuromuscular Blockade, Age, Gender

Received: June 28, 2011; Accepted: September 21, 2011; Prepublished online: November 1, 2011; Published: December 1, 2011  Show citation

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Adamus, M., Hrabalek, L., Wanek, T., Gabrhelik, T., & Zapletalova, J. (2011). INFLUENCE OF AGE AND GENDER ON THE PHARMACODYNAMIC PARAMETERS OF ROCURONIUM DURING TOTAL INTRAVENOUS ANESTHESIA. Biomedical papers, 155(4), 347-353. doi: 10.5507/bp.2011.050
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