Open Access, Peer-reviewed
eISSN 2234-7666
    Restor Dent Endod. 2012 Mar;37(1):2-8. Korean.
    Published online Mar 02, 2012.
    https://doi.org/10.5395/rde.2012.37.1.2
    ©Copyights 2012. The Korean Academy of Conservative Dentistry.
    Review

    Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion

    Jung-Hyun Lee, DDS, PhD student Resident ,1 Juhea Chang, DDS, PhD, Professor ,2 and Ho-Hyun Son, DDS, PhD, Professor 1
      • 1Department of Conservative Dentistry, Seoul National University School of Dentistry, Seoul, Korea.
      • 2Clinic for Persons with Disabilities, Seoul National University Dental Hospital, Seoul, Korea.
    • Correspondence to Ho-Hyun Son, DDS, PhD. Professor, Department of Conservative Dentistry, Seoul National University School of Dentistry and Dental Research Institute, 101 Daehag-ro, Jongro-gu, Seoul, Korea 110-749. TEL, +82-2-2072-2652; Fax, +82-2-2072-3859; Email: hhson@snu.ac.kr
    Received September 06, 2011; Revised November 18, 2011; Accepted November 18, 2011.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    The limited durability of resin-dentin bonds severely compromises the longevity of composite resin restorations. Resin-dentin bond degradation might occur via degradation of water-rich and resin sparse collagen matrices by host-derived matrix metalloproteinases (MMPs). This review article provides overview of current knowledge of the role of MMPs in dentin matrix degradation and four experimental strategies for extending the longevity of resin-dentin bonds. They include: (1) the use of broad-spectrum inhibitors of MMPs, (2) the use of cross-linking agents for silencing the activities of MMPs, (3) ethanol wet-bonding with hydrophobic resin, (4) biomimetic remineralization of water-filled collagen matrix. A combination of these strategies will be able to overcome the limitations in resin-dentin adhesion.

    Keywords
    Biomimetic remineralization; Chlorhexidine; Cross-linking agent; Dentin bonding; Ethanol wet-bonding; Matrix metalloproteinase

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    MeSH Terms
    Biomimetics
    Chlorhexidine
    Collagen
    Dentin
    Ethanol
    Longevity
    Matrix Metalloproteinases
    Metrics
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