Correlation between optical coherence tomography angiography macular parameters with optical coherence tomography structural parameters in primary open angle glaucoma (a longitudinal descriptive study)

https://doi.org/10.53730/ijhs.v6nS7.11492

Authors

  • Hasnaa Hussien Kamel Abdelghani Ophthalmology department, faculty of medicine _Beni-suef University
  • Mansour Hassan Ahmed Professor of Ophthalmology _faculty of medicine _Beni-suef University
  • Hazem Effat Haroun Professor of Ophthalmology _faculty of medicine _Beni-suef University
  • Safaa AwadAllah Mohamed Aboud Assistant Professor of Ophthalmology _faculty of medicine _Beni-suef University

Keywords:

Glaucoma, OCTA, macular circulation, superficial & deep retinal plexuses

Abstract

Background: There is growing evidence indicating that glaucoma pathogenesis is attributed to vascular dysfunction.Aim: compare the macular circulation in normal individuals and glaucomatous patients in the superficial as well as the deep retinal plexuses, to determine and characterize macular circulation deficits in glaucoma along with correlating them with structural macular OCT parameters Methods: descriptive study included 100 eyes of 100 participants who were selected randomly from attendants of ophthalmology outpatient clinic in Beni-suef university hospital Participants were subjected to 24-2 SITA- standard automated VF test using SAP ,OCT ONH examination and OCTA (Macula)  Results: IOP showed significant negative moderate to strong linear correlation with all the Macular Parameters in Glaucoma Participants. These correlations were highly significant; (p-values <0.001). All measurements of superficial and deep macular venues plexuses by studied macular OCTA was statistically significantly lower in glaucomatous as compared to non-glaucomatous participants; (p-values <0.001). Conclusion: There was a reduction in VD in particular that of superficial layer in POAG patients in macular region, according to OCTA measurements. Glaucomatous eyes have a significantly sparser superficial VD in the macula when compared to healthy eyes, and these VD assessments are significantly accompanied by the severity of VF destruction and OCT structural affection.

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References

Chao SC, Yang SJ, Chen HC, Sun CC, Liu CH, Lee CY. Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects. J Ophthalmol. 2019 Jan 15;2019:7419470.

Chen HS-L, Liu C-H, Wu W-C, Tseng H-J, Lee Y-S. Optical coherence tomography angiography of the superficial microvasculature in the macular and peripapillary areas in glaucomatous and healthy eyes. Invest Ophthalmol Vis Sci. 2017;58:3637– 3645

Coscas F, Sellam A, Glacet-Bernard A, Jung C, Goudot M, Miere A, Souied EH. Normative Data for Vascular Density in Superficial and Deep Capillary Plexuses of Healthy Adults Assessed by Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT211-23.

Henry Shen-Lih Chen, Chun-Hsiu Liu, Wei-Chi Wu, Hsiao-Jung Tseng, Yung-Sung Lee; Optical Coherence Tomography Angiography of the Superficial Microvasculature in the Macular and Peripapillary Areas in Glaucomatous and Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2017;58(9):3637-3645.

Hou, TY., Kuang, TM., Ko, YC. et al. Optic Disc and Macular Vessel Density Measured by Optical Coherence Tomography Angiography in Open-Angle and Angle-Closure Glaucoma. Sci Rep 10, 5608 (2020).

Jeoung JW, Choi YJ, Park KH, Kim DM and Jeoung JH . Macular ganglion cell imaging study: glaucoma diagnostic accuracy of spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci 2013; 54:4422–9.

Jia Y, Bailey ST, Hwang TS, McClintic SM, Gao SS, Pennesi ME, Flaxel CJ, Lauer AK, Wilson DJ and Hornegger J: Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye. Proceedings of the National Academy of Sciences 2015, 112(18):E2395-E2402.

Köse HC, Tekeli O. Optical coherence tomography angiography of the peripapillary region and macula in normal, primary open angle glaucoma, pseudoexfoliation glaucoma and ocular hypertension eyes. Int J Ophthalmol. 2020 May 18;13(5):744-754.

Li Z, Xu Z, Liu Q, Chen X, Li L (2020) Comparisons of retinal vessel density and glaucomatous parameters in optical coherence tomography angiography. PLOS ONE 15 : 0234816

Lommatzsch C, Rothaus K, Koch JM, Heinz C, Grisanti S. OCTA vessel density changes in the macular zone in glaucomatous eyes. Graefes Arch Clin Exp Ophthalmol. 2018 Aug;256(8):1499-1508 .

Mansouri K .Optical coherence tomography angiography and glaucoma: searching for the missing link. Expert Rev Med Devices 2016; 6:1–2.

Nesma S. M. Changes of Macular Vessel Density in Primary Open Angle Glaucoma .The Egyptian Journal of Hospital Medicine April 2021 Vol. 83,1129-1133.

Rao HL, Pradhan ZS, Weinreb RN, Reddy HB, Riyazuddin M, Dasari S, Palakurthy M, Puttaiah NK, Rao DA, Webers CA. Regional Comparisons of Optical Coherence Tomography Angiography Vessel Density in Primary Open-Angle Glaucoma. Am J Ophthalmol. 2016 Nov; 171:75-83.

Shahlaee A, Samara WA, Hsu J. In Vivo Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography. Am J Ophthalmol 2016; 165:39-46.

Suh MH, Zangwill LM and Manalastas PI,. Optical coherence tomography angiography vessel density in glaucomatous eyes with focal lamina cribrosa defects. Ophthalmology. 2016; 123:2309-2317.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Takusagawa HL, Liu L, Ma KN, et al. Projection resolved optical coherence tomography angiography of macular retinal circulation in glaucoma. Ophthalmology 2017;124:1589-99.

Tan O, Chopra V, Lu AT, Schuman JS, Ishikawa H, Wollstein G, Varma R, Huang D. Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography. Ophthalmology. 2009 Dec;116(12):2305-14.e1-2.

Tham YC, Li X, Wong TY , Quigley HA, Aung , Cheng CY Global prevalence of glaucoma and projections of glaucoma burden through2040: a systematic review and meta-analysis. Ophthalmology 2014; 121(11):2081–2090

Tokayer J, Jia Y, Dhalla AH, Huang D. Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Biomed Opt Express. 2013;4:1909–1924.

Triolo G, Rabiolo A, Shemonski ND, Fard A, Di Matteo F, Sacconi R, Bettin P, Magazzeni S, Querques G, Vazquez LE, Barboni P, Bandello F. Optical Coherence Tomography Angiography Macular and Peripapillary Vessel Perfusion Density in Healthy Subjects, Glaucoma Suspects, and Glaucoma Patients. Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5713-5722.

Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA 2014; 311:1901-11.

Yarmohammadi A, Zangwill LM, Diniz-Filho A, Suh MH, Manalastas PI, Fatehee N, Yousefi S, Belghith A, Saunders LJ, Medeiros FA, Huang D, Weinreb RN. Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT451-9.

Yu J, Jiang C, Wang X, Zhu L, Gu R, Xu H, Jia Y, Huang D, Sun X. Macular perfusion in healthy Chinese: an optical coherence tomography angiogram study. Invest Ophthalmol Vis Sci. 2015 May;56(5):3212-7.

Zhang M, Hwang TS, Campbell JP, Bailey ST, Wilson DJ, Huang D and Jia Y: Projection-resolved optical coherence tomographic angiography. Biomedical optics express 2016, 7(3):816-828.

Published

02-08-2022

How to Cite

Abdelghani, H. H. K., Ahmed, M. H., Haroun, H. E., & Aboud, S. A. M. (2022). Correlation between optical coherence tomography angiography macular parameters with optical coherence tomography structural parameters in primary open angle glaucoma (a longitudinal descriptive study). International Journal of Health Sciences, 6(S7), 1012–1029. https://doi.org/10.53730/ijhs.v6nS7.11492

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Section

Peer Review Articles