NLR receptor networks in plants
Creators
- 1. Nara Institute of Science and Technology, Japan
- 2. The Sainsbury Laboratory, United Kingdom
Description
To fight off diverse pathogens and pests, the plant immune system must recognize these invaders; however, as plant immune receptors evolve to recognize a pathogen, the pathogen often evolves to escape this recognition. Plant–pathogen co-evolution has led to the vast expansion of a family of intracellular immune receptors—nucleotide-binding domain and leucine-rich repeat proteins (NLRs). When an NLR receptor recognizes a pathogen ligand, it activates immune signaling and thus initiates defense responses. However, in contrast to the model of NLRs acting individually to activate resistance, an emerging paradigm holds that plants have complex receptor networks where the large repertoire of functionally specialized NLRs operate together to act against an equally large repertoire of rapidly evolving pathogen effectors. In this article, we highlight key aspects of immune receptor networks in plant NLR biology and discuss NLR network architecture, the advantages of this receptor network system, and the evolution of the NLR network in asterid plants.
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Biochemist_2022_NLR-receptor-networks_ZENODO.pdf
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Additional details
Funding
- BLASTOFF – Retooling plant immunity for resistance to blast fungi 743165
- European Commission
- Evolution BBS/E/J/000PR9798
- UK Research and Innovation
- Mechanisms of pathogen suppression of NLR-mediated immunity BB/V002937/1
- UK Research and Innovation
- Recognition BBS/E/J/000PR9795
- UK Research and Innovation