İstanbul Journal of Pharmacy

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DOI :10.5152/IstanbulJPharm.2017.0010   IUP :10.5152/IstanbulJPharm.2017.0010    Full Text (PDF)

MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population

Ezgi Öztaş, Umay Çilingir, Ahmet Akyüz, Hakan Teoman Yanar, Gül Özhan

Colorectal cancer (CRC) comprises approximately 10% of all cancers and is a major cause of cancer-related morbidity and mortality despite current diagnostic and treatment improvements. DNA damage and altered DNA replication through the deregulation of related genes cause genomic instability in sporadic CRC. DNA repair is very complex; many factors play a role to ensure that the restoration of errors occurs during the transfer of genetic material. MutL homolog 1 (MLH1) is one of the vital DNA repair genes responsible for genomic stability. Together with environmental factors, the genetic background may be associated with CRC development; thus, genetic polymorphisms are considered as risk factors. The present prospective case– control study aimed to determine the association between 93G>A and I219V polymorphisms of MLH1 and CRC susceptibility in a Turkish population. The genotyping of 158 patients and 164 age- and sex-matched controls was performed by polymerase chain reaction-restriction fragment length polymorphism. Two variants, 93G>A and I219V, were associated with an increased risk of CRC. Individuals with A allele of 93G>A had an approximately 2-fold risk (OR: 1.92, 95% CI: 1.22–3.04; p<0.01) and those with G allele of I219V had an approximately 3-fold risk (OR: 2.82, 95% CI: 1.76–4.52; p<0.01) of developing CRC. Our results provide novel information for understanding the influence of MLH1 on CRC risk in the Turkish population; however, further studies with a larger number of participants are required.

Keywords: MLH1 polymorphism, colorectal cancer, PCR-RFLP

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APA

Öztaş, E., Çilingir, U., Akyüz, A., Yanar, H., & Özhan, G. (2017). MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population. İstanbul Journal of Pharmacy, 47(2), 63-67. https://doi.org/10.5152/IstanbulJPharm.2017.0010


AMA

Öztaş E, Çilingir U, Akyüz A, Yanar H, Özhan G. MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population. İstanbul Journal of Pharmacy. 2017;47(2):63-67. https://doi.org/10.5152/IstanbulJPharm.2017.0010


ABNT

Öztaş, E.; Çilingir, U.; Akyüz, A.; Yanar, H.; Özhan, G. MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population. İstanbul Journal of Pharmacy, [Publisher Location], v. 47, n. 2, p. 63-67, 2017.


Chicago: Author-Date Style

Öztaş, Ezgi, and Umay Çilingir and Ahmet Akyüz and Hakan Teoman Yanar and Gül Özhan. 2017. “MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population.” İstanbul Journal of Pharmacy 47, no. 2: 63-67. https://doi.org/10.5152/IstanbulJPharm.2017.0010


Chicago: Humanities Style

Öztaş, Ezgi, and Umay Çilingir and Ahmet Akyüz and Hakan Teoman Yanar and Gül Özhan. “MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population.” İstanbul Journal of Pharmacy 47, no. 2 (Apr. 2024): 63-67. https://doi.org/10.5152/IstanbulJPharm.2017.0010


Harvard: Australian Style

Öztaş, E & Çilingir, U & Akyüz, A & Yanar, H & Özhan, G 2017, 'MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population', İstanbul Journal of Pharmacy, vol. 47, no. 2, pp. 63-67, viewed 25 Apr. 2024, https://doi.org/10.5152/IstanbulJPharm.2017.0010


Harvard: Author-Date Style

Öztaş, E. and Çilingir, U. and Akyüz, A. and Yanar, H. and Özhan, G. (2017) ‘MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population’, İstanbul Journal of Pharmacy, 47(2), pp. 63-67. https://doi.org/10.5152/IstanbulJPharm.2017.0010 (25 Apr. 2024).


MLA

Öztaş, Ezgi, and Umay Çilingir and Ahmet Akyüz and Hakan Teoman Yanar and Gül Özhan. “MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population.” İstanbul Journal of Pharmacy, vol. 47, no. 2, 2017, pp. 63-67. [Database Container], https://doi.org/10.5152/IstanbulJPharm.2017.0010


Vancouver

Öztaş E, Çilingir U, Akyüz A, Yanar H, Özhan G. MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population. İstanbul Journal of Pharmacy [Internet]. 25 Apr. 2024 [cited 25 Apr. 2024];47(2):63-67. Available from: https://doi.org/10.5152/IstanbulJPharm.2017.0010 doi: 10.5152/IstanbulJPharm.2017.0010


ISNAD

Öztaş, Ezgi - Çilingir, Umay - Akyüz, Ahmet - Yanar, Hakan Teoman - Özhan, Gül. “MLH1 -93G>A and I219V polymorphisms are susceptible to increased risk of sporadic colorectal cancer in a Turkish population”. İstanbul Journal of Pharmacy 47/2 (Apr. 2024): 63-67. https://doi.org/10.5152/IstanbulJPharm.2017.0010



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Accepted08.08.2017

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