Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients

Hind S. AboShabaan; Osama Alghannam; Faisal Ismail; Islam M. El-Garawani; Mohamed El-Shahat; Roba M. Talaat; Eman A. El-maadawy; Nasser Hussein; Zeinab A. Kasemy; Eman Abdelsameea; Soghra Haq; Heba M. Hathout

doi:10.5114/ceh.2023.128616

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients

Hind S. AboShabaan

¹

,

Osama Alghannam

²

,

Faisal Ismail

^{3, 4, 5}

,

Islam M. El-Garawani

⁶

,

Mohamed El-Shahat

⁷

,

Roba M. Talaat

⁷

,

Eman A. El-maadawy

⁷

,

Nasser Hussein

⁷

,

Zeinab A. Kasemy

⁸

,

Eman Abdelsameea

⁹

,

Soghra Haq

³

,

Heba M. Hathout

¹⁰

Department of Clinical Pathology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt
Department of Chemistry, Faculty of Science, Menoufia University, Menoufia, Egypt
Department of Clinical Laboratory, Faculty of Medical Technology, University of Tobruk, Libya
Department of Blood Transmitted Diseases, National Centre for Disease Control, Tobruk, Libya
Department of Infectious Diseases, Libyan Medical Research Centre, Kambut, Tobruk, Libya
Department of Zoology, Faculty of Science, Menoufia University, Menoufia, Egypt
Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat City, Egypt
Department of Public Health and Community Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt
Department of Natural Resources, Faculty of African Postgraduate Studies, Cairo University, Giza, Egypt

Clin Exp HEPATOL 2023; 9, 2: 154-163

DOI: https://doi.org/10.5114/ceh.2023.128616

Online publish date: 2023/06/30

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AMA

AboShabaan H, Alghannam O, Ismail F, et al. Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients. Clinical and Experimental Hepatology. 2023;9(2):164-171. doi:10.5114/ceh.2023.128616.

APA

AboShabaan, H., Alghannam, O., Ismail, F., El-Garawani, I., El-Shahat, M.,  & Talaat, R. et al. (2023). Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients. Clinical and Experimental Hepatology, 9(2), 164-171. https://doi.org/10.5114/ceh.2023.128616

Chicago

AboShabaan, Hind S., Osama Alghannam, Faisal Ismail, Islam M. El-Garawani, Mohamed El-Shahat, Roba M. Talaat,  and Eman A. El-maadawy et al. 2023. "Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients". Clinical and Experimental Hepatology 9 (2): 164-171. doi:10.5114/ceh.2023.128616.

Harvard

AboShabaan, H., Alghannam, O., Ismail, F., El-Garawani, I., El-Shahat, M., Talaat, R., El-maadawy, E., Hussein, N., Kasemy, Z., Abdelsameea, E., Haq, S.,  and Hathout, H. (2023). Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients. Clinical and Experimental Hepatology, 9(2), pp.164-171. https://doi.org/10.5114/ceh.2023.128616

MLA

AboShabaan, Hind S. et al. "Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients." Clinical and Experimental Hepatology, vol. 9, no. 2, 2023, pp. 164-171. doi:10.5114/ceh.2023.128616.

Vancouver

AboShabaan H, Alghannam O, Ismail F, El-Garawani I, El-Shahat M, Talaat R et al. Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients. Clinical and Experimental Hepatology. 2023;9(2):164-171. doi:10.5114/ceh.2023.128616.

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Aim of the study:
Bone morphogenic proteins (BMPs) have both inhibitory and stimulatory effects on growth of a tumor that depend on the type of cells, the dosage and the tumor microenvironment. We aimed to investigate the impact of the bone morphogenic protein-7 (BMP-7) single nucleotide polymorphism (SNP) rs230205 [A/G] on susceptibility to hepatocellular carcinoma (HCC) progression from liver cirrhosis after viral hepatitis infection in Egyptian patients.

Material and methods:
The amplification-refractory mutation system (ARMS)-polymerase chain reaction (PCR) method was used to genotype the rs230205 [A/G] SNP in 150 subjects (50 patients with post-hepatitis C or B cirrhosis, 50 HCC patients, and 50 controls). Expression level of BMP-7 protein was assessed using enzyme-linked immunosorbent assay (ELISA).

Results:
The results revealed insignificant changes in distribution of all genotypes/alleles of the BMP-7 rs230205 [A/G] SNP between cirrhotic patients, HCC patients and controls. The AA genotype and A allele could be considered risk factors for cirrhosis (OR = 1.75, 1.50) and HCC (OR = 2.19, 1.74), respectively. The AA genotype (95% CI: 0.45-6.79) and A allele (OR = 1.50, 95% CI: 0.77-2.93) may be viewed as cirrhosis risk factors based on group segregation. Additionally, the A allele, AG and AA genotypes and their combined ORs of 2.19 (95% CI: 0.58-8.23), 1.74 (95% CI: 0.90-3.37), and 1.70 (95% CI: 0.68-4.29) could all be risk factors for HCC. No genotype or allele could be regarded as a risk factor for progression of cirrhosis to HCC, according to OR values.

Conclusions:
The results showed no correlation between BMP-7 rs230205 [A/G] SNP and progression of cirrhosis to HCC. To confirm our findings, additional prospective large-scale research is required.

keywords:

Bone morphogenic protein-7 (BMP-7) polymorphism: Susceptibility to cirrhosis and hepatocellular carcinoma after viral hepatitis in Egyptian patients

Hind S. AboShabaan 1 , Osama Alghannam 2 , Faisal Ismail 3, 4, 5 , Islam M. El-Garawani 6 , Mohamed El-Shahat 7 , Roba M. Talaat 7 , Eman A. El-maadawy 7 , Nasser Hussein 7 , Zeinab A. Kasemy 8 , Eman Abdelsameea 9 , Soghra Haq 3 , Heba M. Hathout 10

bone morphogenic protein (BMP)-7, single nucleotide polymorphism (SNP), liver cirrhosis, hepatocellular carcinoma (HCC)