Identification of Lymphocyte Subsets in Leprosin Positive Sites Following Vaccination

N. M. SAMUEL; S. SILWAL; S. SAMUEL; J. LOUDON

doi:10.5025/hansen1977.54.18

Identification of Lymphocyte Subsets in Leprosin

Positive Sites Following Vaccination

N. M. SAMUEL, S. SILWAL, S. SAMUEL, J. LOUDON

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JOURNAL FREE ACCESS

1985 Volume 54 Issue 1 Pages 18-24

DOI https://doi.org/10.5025/hansen1977.54.18

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Published: March 30, 1985 Received: September 21, 1984 Available on J-STAGE: February 26, 2008 Accepted: - Advance online publication: - Revised: -
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Date of correction: February 26, 2008 Reason for correction: - Correction: TITLE Details: Wrong : Identification of Lymphocyte Subsets in Leprosin A Positive Sites Following Vaccination
Right : Identification of Lymphocyte Subsets in Leprosin

Date of correction: February 26, 2008 Reason for correction: - Correction: SUBTITLE Details: Right : Positive Sites Following Vaccination

Date of correction: February 26, 2008 Reason for correction: - Correction: ABSTRACT Details: Right : In Leprosy a skin test has been prepared by Rees from armadillo tissues carefully freed from armadillo antigen. This reagent is called Leprosin A. Several healthy normals, contacts and leprosy patients negative to Leprosin A were vaccinated with a mixture of M. leprae plus BCG. Forty four Leprosin A positive sites were biopsied following the vaccination. Immuno peroxidase technique with monoclonal antibodies has been used to identify T cells, T helper cells and T suppressor cells. Enumeration of the T Cell subsets shows that the large number infiltrating the positive skin test sites are T helper-induce subset. Multibacillary leprosy patients following the vaccination demonstrated large numbers of T helper-inducer lymphocytes. We speculate that the T helper cells are due to the immunostimulating properties of the M. leprae plus BCG.

Date of correction: February 26, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: February 26, 2008 Reason for correction: - Correction: PDF FILE Details: -

Abstract

In Leprosy a skin test has been prepared by Rees from armadillo tissues carefully freed from armadillo antigen. This reagent is called Leprosin A. Several healthy normals, contacts and leprosy patients negative to Leprosin A were vaccinated with a mixture of M. leprae plus BCG. Forty four Leprosin A positive sites were biopsied following the vaccination. Immuno peroxidase technique with monoclonal antibodies has been used to identify T cells, T helper cells and T suppressor cells. Enumeration of the T Cell subsets shows that the large number infiltrating the positive skin test sites are T helper-induce subset. Multibacillary leprosy patients following the vaccination demonstrated large numbers of T helper-inducer lymphocytes. We speculate that the T helper cells are due to the immunostimulating properties of the M. leprae plus BCG.

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