Ann Dermatol. 2007 Dec;19(4):160-162. English.
Published online Dec 31, 2007.
https://doi.org/10.5021/ad.2007.19.4.160
Published online Dec 31, 2007.
https://doi.org/10.5021/ad.2007.19.4.160
Copyright © 2007 The Korean Dermatological Association and The Korean Society for Investigative Dermatology
Case Report
A Case of Methotrexate-induced Bullous Acral Erythema
Abstract
Chemotherapy-induced acral erythema (CIAE) is a toxic reaction to a number of different chemotherapeutic agents, and causes symmetrical, well-demarcated, painful erythema on the palms and soles which is self-limiting. CIAE with bullous reaction in relation to methotrexate has been reported, but it is more commonly associated with cytosine arabinoside. The differential diagnosis of this condition from more serious conditions such as graft-vs-host disease or toxic epidermal necrolysis is essential.
In this paper, we report the case of a 65-year-old man who developed bullous acral erythema after the administration of high-dose methotrexate for the treatment of Non-Hodgkin's lymphoma.
Keywords
Methotrexate; Bullous acral erythema
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