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Fenotypy astmy oskrzelowej zidentyfikowane przy zastosowaniu analizy skupień
Aneta Grabowska-Popek
Abstract
Bronchial asthma is a chronic disease that give a series of symptoms. Currently, research is ongoing to identify a new phenotypes of bronchial asthma and their characteristics. The aim of the study: was to identify new phenotypes of bronchial asthma using cluster analysis, on the basis of the proposed variables. Material and methods: the study included 169 patients aged 45 to 64 years (average was 57) with diagnosed bronchial asthma, living in the south-eastern part of the Podkarpackie voivodeship. The study included persons with a diagnosis of bronchial asthma according to the GINA criteria, treated for at least 12 months in a stable period of this disease. Subjects were recruited among hospital clinic patients of Tuberculosis and Lung Diseases at the Provincial Hospital Saint Father Pio in Przemyśl. The following tests were performed in the tested group: medical interview, physical examination, a specially prepared questionnaire, spirometry with a trial of relaxation, blood was collected to determine the concentration of selected laboratory parameters and the level of educational and reproductive abilities of the patients was measured using Raven Matrices Test. Results: patients from cluster III (33.2%) predominated in the study group (long-term asthma with obstruction and frequent exacerbations), 29% of subjects were patients with cluster I (elderly people asthma with late onset and multiple comorbidities), 18.9% of the subjects were cluster II (obesity asthma phenotype with activation of „pro-inflammatory” and „allergic" cytokines) and analogously (18.9%) of patients qualified for cluster IV (early-onset asthma). Conclusions: 1. The analysis included to identify four phenotypes of bronchial asthma: a). bronchial asthma phenotype in the elderly with late onset disease and co-morbidities, b). phenotype of obese people with the activity of "pro-inflammatory" and "allergic" cytokines, c). long-term asthma phenotype, with obstruction and frequent exacerbations, d). phenotype of young people with early onset of the disease with allergic goods not used by us and positive family history of bronchial asthma. 2. The identified phenotypes (clusters) of bronchial asthma differed in terms of patient education and frequency of drug use (SABA and ICS).- Record ID
- SUM62243124c90d42e498bbc1728fa600dc
- Diploma type
- Doctor of Philosophy
- Author
- Title in Polish
- Fenotypy astmy oskrzelowej zidentyfikowane przy zastosowaniu analizy skupień
- Language
- (pl) Polish
- Certifying Unit
- Medical University of Silesia (SUM)
- Status
- Finished
- Year of creation
- 2020
- Defense Date
- 12-04-2021
- Title date
- 22-04-2021
- Supervisor
- External reviewers
- License
- DOI
- DOI:10.48745/ppm.f4x1-3747 Opening in a new tab
- Keywords in English
- asthma, cluster analysis, phenotype, cluster
- Abstract in English
- Bronchial asthma is a chronic disease that give a series of symptoms. Currently, research is ongoing to identify a new phenotypes of bronchial asthma and their characteristics. The aim of the study: was to identify new phenotypes of bronchial asthma using cluster analysis, on the basis of the proposed variables. Material and methods: the study included 169 patients aged 45 to 64 years (average was 57) with diagnosed bronchial asthma, living in the south-eastern part of the Podkarpackie voivodeship. The study included persons with a diagnosis of bronchial asthma according to the GINA criteria, treated for at least 12 months in a stable period of this disease. Subjects were recruited among hospital clinic patients of Tuberculosis and Lung Diseases at the Provincial Hospital Saint Father Pio in Przemyśl. The following tests were performed in the tested group: medical interview, physical examination, a specially prepared questionnaire, spirometry with a trial of relaxation, blood was collected to determine the concentration of selected laboratory parameters and the level of educational and reproductive abilities of the patients was measured using Raven Matrices Test. Results: patients from cluster III (33.2%) predominated in the study group (long-term asthma with obstruction and frequent exacerbations), 29% of subjects were patients with cluster I (elderly people asthma with late onset and multiple comorbidities), 18.9% of the subjects were cluster II (obesity asthma phenotype with activation of „pro-inflammatory” and „allergic" cytokines) and analogously (18.9%) of patients qualified for cluster IV (early-onset asthma). Conclusions: 1. The analysis included to identify four phenotypes of bronchial asthma: a). bronchial asthma phenotype in the elderly with late onset disease and co-morbidities, b). phenotype of obese people with the activity of "pro-inflammatory" and "allergic" cytokines, c). long-term asthma phenotype, with obstruction and frequent exacerbations, d). phenotype of young people with early onset of the disease with allergic goods not used by us and positive family history of bronchial asthma. 2. The identified phenotypes (clusters) of bronchial asthma differed in terms of patient education and frequency of drug use (SABA and ICS).
- MeSH
- Thesis file
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- File: 1
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Fenotypy astmy oskrzelowej zidentyfikowane przy zastosowaniu analizy skupień, File Grabowska-Popek Aneta.pdf / 2 MB
- Grabowska-Popek Aneta.pdf
- publication date: 21-07-2021
- Fenotypy astmy oskrzelowej zidentyfikowane przy zastosowaniu analizy skupień, File Grabowska-Popek Aneta.pdf / 2 MB
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- File: 2
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Fenotypy astmy oskrzelowej zidentyfikowane przy zastosowaniu analizy skupień, File Grabowska-Popek Aneta.wcag.pdf / 899 KB
- Grabowska-Popek Aneta.wcag.pdf
- publication date: 30-07-2021
- Fenotypy astmy oskrzelowej zidentyfikowane przy zastosowaniu analizy skupień, File Grabowska-Popek Aneta.wcag.pdf / 899 KB
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- Uniform Resource Identifier
- https://ppm.edu.pl/info/phd/SUM62243124c90d42e498bbc1728fa600dc/
- URN
urn:umed-ppm-prod:SUM62243124c90d42e498bbc1728fa600dc