El Fatemi Hinde, Florence Mishellany, Pierre Gimbergues, Frédérique Penault-Llorca
Department of Pathology, Centre Jean-Perrin, Clermont-Ferrand, France.
Department of Pathology, Hassan II Teaching Hospital, Fez, Morocco.
Department of Surgery, Centre Jean-Perrin, Clermont-Ferrand, France.
DOI: 10.4236/ojpathology.2012.24026   PDF    HTML     3,617 Downloads   5,727 Views   Citations

Abstract

Introduction: Hyalinizing spindle cell tumor with giant rosettes (HSCT) is a very uncommon mesenchymal tumor that has similar morphological and biological features to the low-grade fibromyxoid sarcoma (LGFMS). Case Report: Reported herein is a case of primary tumour of buttock HSCT that had rare FUS-CREB3L1 fusion transcripts, a product of characteristic chromosomal abnormality t (7; 16) (q33; p11) of HSCT and LGFMS. The patient was a 48-year-old man who had a large solitary mass in the buttock. Histologically, it was composed of bland spindle cells with variable cellularity deposited in a densely hyalinized stroma alternating with myxoid areas. Characteristic collagen rosettes were scattered in the cellular areas. Reverse transcription-polymerase chain reaction (RT-PCR) assay using formalin-fixed, paraffin-embedded tissue detected FUS-CREB3L1 fusion transcripts. In our knowledge is the second case may display a variant FUS/CREB3L1 fusion transcript in international literature. Conclusion: LGFMS and HSCT probably have a wider spectrum of morphologic features than previously thought, the awareness of which will help pathologists to avoid diagnostic pitfalls. Demonstration of the t (7; 16) translocation will help to diagnose difficult cases with unusual histologic features.

Keywords

Deep Soft Tissue; Fibromyxoid Sarcoma; Hyalinizing Spindle Cell Tumor; RT-PCR; Fusion Transcripts; CREB3L1

Share and Cite:

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	G. P. Nielsen, M. K. Selig, J. X. O’Connell, S. B. Keel, G. R. Dickersin and A. E. Rosenberg, “Hyalinizing Spindle Cell Tumor with Giant Rosettes: A Report of Three Cases with Ultrastructural Analysis,” American Journal of Surgical Pathology, Vol. 23, No. 10, 1999, pp. 1227-1232.
[2]	K. L. Lane, R. J. Shannon and S. W. Weiss, “Hyalinizing Spindle Cell Tumor with Giant Rosettes. A Distinctive Tumor Closely Resembling Low-Grade Fibromyxoid Sarcoma,” American Journal of Surgical Pathology, Vol. 21, No. 12, 1997, pp. 1481-1488.
[3]	A. L. Folpe, K. L. Lane, G. Paull and S. W. Weiss, “Low-Grade Fibromyxoid Sarcoma and Hyalinizing Spindle Cell Tumor with Giant Rosettes. A Clinicopathologic Study of 73 Cases Supporting Their Identity and Assessing the Impact of High-Grade Areas,” American Journal of Surgical Pathology, Vol. 24, No. 10, 2000, pp. 1353-1360.
[4]	R. Reid, C. Silva, L. Paterson, E. Ryan and C. Fisher, “Low-Grade Fibromyxoid Sarcoma and Hyalinizing Spindle Cell Tumor with Giant Rosettes Share a Common t(7; 16)(q34; p11) Translocation,” American Journal of Surgical Pathology, Vol. 27, No. 9, 2003, pp. 1229-1236.
[5]	A. Matsuyama, M. Hisaoka, S. Shimajiri, et al., “Molecular Detection of FUS-CREB3L2 Fusion Transcripts in Low-Grade Fibromyxoid Sarcoma Using Formalin-Fixed, Paraffin-Embedded Tissue Specimens,” American Journal of Surgical Pathology, Vol. 30, No. 9, 2006, pp. 1077-1084.
[6]	S. W. Weiss and J. R. Goldblum, “Enzinger and Weiss’s Soft Tissue Tumors,” 4th Edition, Mosby, St. Louis, 2001, pp. 431-435.
[7]	S. E. Vernon and P. A. Bejarano, “Low Grade Fibromyxoid Sarcoma: A Brief Review,” Archives of Pathology & Laboratory Medicine, Vol. 130, No. 9, 2006, pp. 1358-1360.
[8]	T. Hansen, K. Katenkamp, M. Brodhun and D. Katenkamp, “Low-Grade Fibrosarcoma—Report on 39 Not Otherwise Specified Cases and Comparison with Defined Low-Grade Fibrosarcoma Types,” Histopathology, Vol. 39, No. 4, 2006, pp. 152-160.
[9]	J. M. Woodruff, C. R. Antonescu, R. A. Erlandson and P. J. Boland, “Low Grade Fibrosarcoma with Palisaded Granulomalike Bodies (Giant Rosettes): Report of a Case That Metastasized,” American Journal of Surgical Pathology, Vol. 23, 1999, pp. 1423-1428. doi:10.1097/00000478-199911000-00015
[10]	F. Mertens, C. D. Fletcher, C. R. Antonescu, J. M. Coindre, M. Colecchia, et al., “Clinicopathologic and Molecular Genetic Characterization of Low-Grade Fibromyxoid Sarcoma, and Cloning of a Novel FUS/CREB3L1 Fusion Gene,” Laboratory Investigation, Vol. 85, No. 3, 2005, pp. 408-415. doi:10.1038/labinvest.3700230