Does FMF have a property to protect children from obesity?

Abstract

Objectives: This study investigates the prevalence of obesity in children with familial Mediterranean fever (FMF). Material and Methods: We retrospectively reviewed the medical records of 70 patients with FMF whose cases had been followed in our Pediatric Nephrology and Rheumatology Unit. The height and weight measurements of children with FMF were obtained and body mass index was calculated. Results: The mean body mass index was 16.7± 2.4 in the boys, and 17.4±2.9 in the girls. Nine of the children (five boys, four girls) were found to be overweight, a rate of 12.8% in FMF patients. Obesity was not detected in FMF patients. Conclusions: We think that there are some unligteening molecular mechanisms that prevent obesity in FMF patients. Due to the limited number of patients in this study, further research involving more patients are needed.

Share and Cite:

Gok, F. , Dursun, l. and Gokce, l. (2010) Does FMF have a property to protect children from obesity?. Health, 2, 268-271. doi: 10.4236/health.2010.23038.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Sohar, E., Gafni, J., Pras, M. and Heller, H. (1967) Familial Mediterranean fever: A survey of 470 cases and review of the literature. American Journal of Medicine, 43, 227-253.
[2] Hashkes, P.J. (2002) Amyloidosis and familial Mediterranean fever. In: Rudolph, C.D., Rudolph, A.M., Hostetter, M.K., Lister, G., S?egel, N.J. (eds), Rudolph’s Pediatrics (21st Editon), McGraw-Hill, New York, 864-866.
[3] Pras, M., Zemer, D., Langewitz, P. and Sohar, E. (1992) Familial Mediterranean fever: A genetic disorder prevalent in Sepharadi Jews. In: Bonne-Tamir, B., Adam, A. (eds), Genetic Diversity Among Jews: Diseases and Markers at the DNA Level, Oxford University Press, Oxford, 223-227.
[4] Oz?akar, Z.B., Yal?inkaya, F., Yüksel, S., Acar, B., G?kmen, D. and Ekim, M. (2006) Possible effect of subclinical inflammation on daily life in familial Mediterranean fever. Clinical Rheumatology, 25, 149-152.
[5] Yudkin, J.S. (2003) Adipose tissue, insulin action and vascular disease: Inflammatory signals. International Journal of Obesity and Related Metabolic Disorders, 27, 25-28.
[6] Das, U.N. (2001) Is obesity an inflammatory condition? Nutrition, 17, 953-966.
[7] Savgan-Gürol, E., Kasap?opur, O., Hatemi, S., Ercan, O., Caliskan, S., Sever, L., Ozdogan, H. and Arisoy, N. (2001) Growth and IGF-1 levels of children with familial Mediterranean fever on colchicine treatment. Clinical and Experimental Rheumatology, 19, 72-75.
[8] Türkmen, M., Soylu, O.B., Kasap, B., Güne?, S., Tüfek?i, O., Soylu, A., Er?al, D. and Kavuk?u, S. (2008) Growth in familial mediterranean fever: Effect of attack rate, genotype and colchicine treatment. Journal of Pediatric Endocrinology and Metabolism, 21, 789-792.
[9] Zung, A., Barash, G., Zadik, Z. and Barash, J. (2006) Familial Mediterranean fever and growth: Effect of disease severity and colchicine treatment. Journal of Pediatric Endocrinology and Metabolism, 19, 155-160.
[10] Onen, F., Sumer, H., Turkay, S., Akyurek, O., Tunca, M. and Ozdogan, H. (2004) Increased frequency of familial Mediterranean fever in Central Anatolia, Turkey. Clinical and Experimental Rheumatology, 22, 31-33.
[11] Bundak, R., Furman, A., Gunoz, H., Darendeliler, F., Bas, F. and Neyzi, O. (2006) Body mass index references for Turkish children. Acta Paediatrica, 95, 194-198.
[12] Livneh, A., Langevitz, P., Zemer, D., Kees, S. and Lidav, T. (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis and Rheumatism, 40, 1879-1885.
[13] Du?unsel, R., Dursun, I., Gündüz, Z., Poyrazo?lu, M.H., Gürg?ze, M.K. and Dundar, M. (2008) Genotype- phenotype correlation in children with familial Mediterranean fever in a Turkish population. Pediatrics International, 50, 208-212.
[14] World Health Organisation (1998) Obesity: Preventing and managing the global epidemic. Report of A WHO Consultation, Geneva, 3-5 June 1997 (WHO/NT/98.1).
[15] Kocaoglu, B.A. and K?ksal, O. (1985) The effect of socioeconomic conditions on growth, development and obesity among adolescents in Turkey. Journal of Nutrition and Dietetics, 14, 25-37.
[16] Cinaz, P., ?amurdan, O. and Maral, I. (2003) 6-16 ya? aras? 12.589 ?ocukta obezite s?kl??? ve risk fakt?rleri. VIII. Ulusal Pediatrik Endokrinoloji Kitab?, 230.
[17] Simsek, E., Akpinar, S., Bahcebasi, T., Senses, D.A. and Kocabay, K. (2008) The prevalence of overweight and obese children aged 6-17 years in the West Black Sea region of Turkey. International Journal of Clinical Practice, 62, 1033-1038.
[18] Simon, D., Fernando, C., Czernichow, P. and Prieur, A.M. (2002) Linear growth and final height in patients with systemic juvenile idiopathic arthritis treated with longterm glucocorticoids. Journal of Rheumatology, 29, 1296-1300.
[19] Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R. and Burn, P. (1995) Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science, 269, 546-549.
[20] Halaas, J.L., Gajiwala, K.S., Maffei, M., Cohen, S.L., Chait, B.T., Rabinowitz, D., Lallone, R.L., Burley, S.K. and Friedman, J.M. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science, 269, 543-546.
[21] Ahima, R.S., Saper, C.B., Flier, J.S. and Elmquist, J.K. (2000) Leptin regulation of neuroendocrine systems. Front Neuroendocrinol, 21, 263-307.
[22] Ronti, T., Lupattelli, G. and Mannarino, E. (2006) The endocrine function of adipose tissue: An update. Clinical Endocrinology, 64, 355-365.
[23] Winer, J.C., Zern, T.L., Taksali, S.E., Dziura, J., Cali, A.M., Wollschlager, M., Seyal, A.A., Weiss, R., Burgert, T.S. and Caprio, S. (2006) Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome. Journal of Pediatric Endocrinology and Metabolism, 91, 4415-4423.
[24] Saltevo, J., Laakso, M., Jokelainen, J., Kein?nen- Kiukaanniemi, S., Kumpusalo, E. and Vanhala, M. (2008) Levels of adiponectin, C-reactive protein and interleukin-1 receptor antagonist are associated with insulin sensitivity: A population-based study. Diabetes/Metabolism Research and Reviews, 24, 378-383.
[25] Antuna-Puente, B., Feve, B., Fellahi, S. and Bastard, J.P. (2008) Adipokines: The missing link between insulin resistance and obesity. Diabetes and Metabolism, 34, 2-11.
[26] Shin, J.H., Shin, D.W. and Noh, M. (2009) Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes. Biochemical Pharmacology, 77, 1835-1844.

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.