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CC BY-NC-ND 4.0 · World J Nucl Med 2020; 19(02): 99-105
DOI: 10.4103/wjnm.WJNM_24_19
Original Article

Comparison of 68Ga-DOTA-NaI3-Octreotide/tyr3-octreotate positron emission tomography/computed tomography and contrast-enhanced computed tomography in localization of tumors in multiple endocrine neoplasia 1 syndrome

Virendra Patil
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra
,
Manjunath Goroshi
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra
,
Hina Shah
1   Department of Nuclear Medicine and Positron Emission Tomography/Computed Tomography, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India
,
Gaurav Malhotra
2   Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Priya Hira
3   Department of Radiology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India
,
Vijaya Sarathi
4   Department of Endocrinology, Narayana Medical College, Nellore, Andhra Pradesh, India
,
Vikram Lele
1   Department of Nuclear Medicine and Positron Emission Tomography/Computed Tomography, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India
,
Swati Jadhav
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra
,
Anurag Lila
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra
,
Tushar Bandgar
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra
,
Nalini Shah
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra
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Abstract

The optimum imaging modality for the screening of multiple endocrine neoplasia type 1 (MEN1)-associated tumors is not well established. Here, we compare the performance of contrast-enhanced CT (CECT) versus 68Ga DOTA-NOC/TATE PET/CT in MEN1 patients. The retrospective case record study is conducted at a tertiary health-care center. Thirty-four patients, who have undergone both CECT and 68Ga DOTA-NOC/TATE PET, were included in the analysis. CECT had higher per-lesion sensitivity than 68Ga DOTA-NOC/TATE PET/CT for the detection of parathyroid lesions, (82.6% vs. 24.6%, P < 0.001). 68Ga DOTA-NOC/TATE PET/CT had higher per-lesion sensitivity than CECT for the detection of metastases (85% vs. 47.5%, P < 0.001) and gastrinomas (90% vs. 10%, P = 0.003). When combined use of the two imaging modalities is compared to CECT alone (63.7% vs. 93.1%, P = 0.00012) and 68Ga-DOTA-NOC/TATE PET/CT alone (74.1% vs. 93.1%, P = 0.0057), it provided significantly higher per-lesion sensitivity for the detection of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). 68Ga-DOTA-NOC/TATE PET was more sensitive for the detection of gastrinomas and metastases than CECT, whereas it was less sensitive for the detection of parathyroid lesions than CECT. The combined use of both the imaging modalities significantly increases the sensitivity for detection of GEP-NETs.

Keywords

68Ga-DOTA-Nai3-octreotide/tyr3-octreotate positron emission tomography/computed tomography - contrast enhanced computed tomography - gastrointestinal-pancreatic neuroendocrine tumor - multiple endocrine neoplasia type 1 imaging - multiple endocrine neoplasia type 1 syndrome

Financial support and sponsorship

Nil.




Publication History

Received: 19 March 2019

Accepted: 18 June 2019

Article published online:
19 April 2022

© 2020. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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