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CC BY-NC-ND 4.0 · World J Nucl Med 2019; 18(04): 409-412
DOI: 10.4103/wjnm.WJNM_111_18
Case Report

Fibrous dysplasia as a possible false-positive finding in 68Ga-labeled prostate-specific membrane antigen positron emission tomography/computed tomography study in the follow-up of prostate cancer

André Marcondes Braga Ribeiro
Department of Nuclear Medicine, A. C. Camargo Cancer Center, São Paulo, Brazil
,
Eduardo Nóbrega Pereira Lima
Department of Nuclear Medicine, A. C. Camargo Cancer Center, São Paulo, Brazil
,
Maurìcio Murce Rocha
1   Department of Urology, A. C. Camargo Cancer Center, São Paulo, Brazil
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Abstract

Positron emission tomography/computed tomography (PET/CT) using 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) has become an important tool in restaging patients with prostate cancer (PCa). Despite its high sensitivity and specificity, this method may produce false-positive findings, as indicated by previous studies. This case report aims to warn nuclear medicine physicians, oncologists, and urologists about the possibility of false-positive findings using this imaging modality, especially when the detected site is unusual for bone metastasis. A 68-year-old man with PCa underwent restaging tests after presenting with increased prostate-specific antigen.68Ga-PSMA PET/CT imaging revealed abnormal uptake in the left humeral head, which anatomically corresponded to the intramedullary and cortical sclerotic area. A biopsy was performed, and the pathology showed a lesion consisting of hard bone tissue with a small focal spot of fibrous dysplasia. Diagnostic issues related to 68Ga-PSMA PET/CT imaging should be disseminated to help physicians make appropriate treatment choices for each patient.

Keywords

68Ga-labeled prostate-specific membrane antigen - bone metastasis - false-positive result - fibrous dysplasia - prostate cancer

Financial support and sponsorship

Nil.




Publication History

Received: 06 December 2018

Accepted: 21 December 2018

Article published online:
22 April 2022

© 2019. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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