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CC BY-NC-ND 4.0 · South Asian J Cancer 2015; 04(02): 083-087
DOI: 10.4103/2278-330X.155691
MINI SYMPOSIUM: MOLECULAR ONCOLOGY: Original Article

Anticancer activity of Cynodon dactylon L. root extract against diethyl nitrosamine induced hepatic carcinoma

R. Kowsalya
Department of Biotechnology, Molecular Pharmacology Research Laboratory, Periyar University, Salem, Tamil Nadu
,
Jagatheesh Kaliaperumal
Department of Biotechnology, Molecular Pharmacology Research Laboratory, Periyar University, Salem, Tamil Nadu
,
M. Vaishnavi
Department of Biotechnology, Molecular Pharmacology Research Laboratory, Periyar University, Salem, Tamil Nadu
,
Elangovan Namasivayam
Department of Biotechnology, Molecular Pharmacology Research Laboratory, Periyar University, Salem, Tamil Nadu
› Author Affiliations Source of Support: Nill.
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Abstract

Background: Hepatocellular carcinoma is one of the most common cancers and a lethal disease. In view of the limited treatment and a grave prognosis of liver cancer, preventive control has been emphasized. Materials and Methods: The methanolic extract of roots of Cynodon dactylon was screened for its hepato-protective activity in diethyl nitrosamine (DEN) induced liver cancer in Swiss albino mice. The plant extract at a dose of 50 mg/kg was administered orally once a week, up to 30 days after DEN administration. The animals were sacrificed; blood sample and liver tissue were collected and used for enzyme assay such as, asparatate amino transferase (AST), alanine aminotransferase (ALT), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST). The liver marker enzymes AST and ALT produced signifi cant results in the protective action. Results: The antioxidant enzyme assay results concerning the improved activity of GPx, GST and CAT. These results concluded that enhanced levels of antioxidant enzyme and reduced amount of serum amino transaminase, which are suggested to be the major mechanisms of C. dactylon root extract in protecting the mice from hepatocarcinoma induced by DEN. These biochemical observations were supplemented by histopathological examination of liver sections. Conclusion: The methanolic extract of C. dactylon possesses signifi cant anticancer properties

Key words

Anticancer - Cynodon dactylon L - marker enzymes - N-diethyl nitrosamine


Publication History

Article published online:
31 December 2020

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