The Effect of Hydroxyethyl Starch and Crystalloid Solutions on Blood Loss and Transfusion Requirement in Patients with Recent Antiplatelet Therapy Undergoing Off-pump Coronary Bypass Surgery.

Ahn,  So Woon; Bang,  Sou Ouk; Chun,  Duck Hee; Lee,  Jong Hwa; Park,  Kyung Bae; Kwak,  Young Lan

doi:2008.54.2.173

Randomized Controlled Trial

Korean Journal of Anesthesiology 2008;54(2):173-177.
DOI: https://doi.org/10.4097/kjae.2008.54.2.173

The Effect of Hydroxyethyl Starch and Crystalloid Solutions on Blood Loss and Transfusion Requirement in Patients with Recent Antiplatelet Therapy Undergoing Off-pump Coronary Bypass Surgery.

So Woon Ahn, Sou Ouk Bang, Duck Hee Chun, Jong Hwa Lee, Kyung Bae Park, Young Lan Kwak

¹Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea. ylkwak@yumc.yonsei.ac.kr
²Anesthesia and Pain Reserch Institute, Yonsei University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND
Hydroxyethylstarch (HES) solutions are commonly used for intravascular volume expansion with varying effect on coagulation depending on molecular weight and mode of hydroxyl substitution.Clopidogrel and aspirin have been shown to reduce cardiovascular complications in patients with coronaryartery occlusive disease which renders patients to higher risk of bleeding complications who require surgery.The purpose of this study was to evaluate the effect of HES 200/0.5, 130/0.4 and crystalloid on blood loss and transfusion requirement in patients with recent antiplatelet therapy undergoing off-pump coronary bypass surgery (OPCAB) in a prospective, randomized trial.
METHODS
Sixty patients scheduled for OPCAB, who received clopidogrel and aspirin within 5 days of surgery were randomly allocated into 3 groups:HES 200/0.5 (n = 20), HES 150/0.4 (n = 20), and Crystalloid (n = 20).Routine coagulation profile were measured before and 2 days after the surgery.Amount of perioperative blood loss, transfusion requirement and fluids input and output were recorded until 2 days postoperatively.
RESULTS
The 3 groups were similar with regard to patients and operative characteristics.There were no significant differences in the amount of perioperative blood loss and transfusion requirement among the 3 groups.
CONCLUSIONS
Both HES solutions were safe to use in terms of blood loss and transfusion requirement in patients undergoing OPCAB who received antiplatelet agents within 5 days of surgery.

Key Words: antiplatelet; blood loss; hydroxyethylstarch (HES); transfusion