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Pediatric Reports
Volume 8
Issue 1
10.4081/pr.2016.6159
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Case Report

The Use of Splenectomy to Manage Platelet Transfusion Refractoriness Due to Anti-Human Leukocyte Antibodies in Allogeneic Stem Cell Transplantation

by
Margherita Mauro
1,
Francesco Camoglio
1,
Pierluigi Piccoli
1,
Massimiliano De Bortoli
1,
Rita Balter
1,
Anna Pegoraro
1 and
Simone Cesaro
1,*
1
Department of Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
2
Department of Pediatric Surgery, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
3
Department of Transfusional Medicine, Azienda Ospedaliera Universitaria Integrata, Verona
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2016, 8(1), 6159; https://doi.org/10.4081/pr.2016.6159
Submission received: 24 August 2015 / Revised: 24 August 2015 / Accepted: 19 December 2015 / Published: 31 March 2016

Abstract

In patients undergoing hematopoietic stem cell transplantation (HSCT), refractoriness to platelet transfusion has been associated with graft failure, delayed engraftment, early mortality and decreased overall survival. Therapeutic strategies include plasma exchange, immunoglobulins, rituximab, and splenectomy. We describe here three patients with refractoriness to platelet transfusion due to anti-human leukocyte antibodies who were splenectomized before HSCT (two cases) and after HSCT (one case) due to the lack of efficacy of other therapies. Splenectomy was uneventful. All three patients achieved a full donor engraftment. We suggest that splenectomy is feasible and effective in HSCT patients to reduce the risk of graft failure or delayed engraftment.
Keywords: anti-HLA; splenectomy; alloimmunized patients; transfusion refractoriness; allogeneic stem cell transplantation anti-HLA; splenectomy; alloimmunized patients; transfusion refractoriness; allogeneic stem cell transplantation

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MDPI and ACS Style

Mauro, M.; Camoglio, F.; Piccoli, P.; De Bortoli, M.; Balter, R.; Pegoraro, A.; Cesaro, S. The Use of Splenectomy to Manage Platelet Transfusion Refractoriness Due to Anti-Human Leukocyte Antibodies in Allogeneic Stem Cell Transplantation. Pediatr. Rep. 2016, 8, 6159. https://doi.org/10.4081/pr.2016.6159

AMA Style

Mauro M, Camoglio F, Piccoli P, De Bortoli M, Balter R, Pegoraro A, Cesaro S. The Use of Splenectomy to Manage Platelet Transfusion Refractoriness Due to Anti-Human Leukocyte Antibodies in Allogeneic Stem Cell Transplantation. Pediatric Reports. 2016; 8(1):6159. https://doi.org/10.4081/pr.2016.6159

Chicago/Turabian Style

Mauro, Margherita, Francesco Camoglio, Pierluigi Piccoli, Massimiliano De Bortoli, Rita Balter, Anna Pegoraro, and Simone Cesaro. 2016. "The Use of Splenectomy to Manage Platelet Transfusion Refractoriness Due to Anti-Human Leukocyte Antibodies in Allogeneic Stem Cell Transplantation" Pediatric Reports 8, no. 1: 6159. https://doi.org/10.4081/pr.2016.6159

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