Significance of Bcl-2 and Bcl-6 Immunostaining in B-Non Hodgkin's lymphoma
Cinical Pathology, Faculty of Medicine, Ain Shams University, ElAbbassia Square, Cairo 11566, Egypt
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Author to whom correspondence should be addressed.
Hematol. Rep. 2011, 3(3), e26; https://doi.org/10.4081/hr.2011.e26
Submission received: 20 August 2011
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Revised: 20 September 2011
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Accepted: 24 October 2011
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Published: 16 November 2011
Abstract
The determination of prognosis for B-Non-Hodgkin’s lymphoma (NHL) is known to be related to the multiple differences in tumor cell biology. Bcl-2 and Bcl-6 are two markers linked to germinal center B cells. Both markers are thought to have an effect on prognosis of mature B-cell neoplasms. Forty-four patients with chronic B-cell neoplasm were included; Bcl-2 and Bcl-6 expression by immunohistochemistry was examined. Bcl-2 protein was positive in 36.4% (16 of 44) of cases (62.5% of follicular lymphoma, 16.7% of mantle cell lymphoma and 30% of diffuse large B-cell lymphoma); the positive group implying a bad prognostic effect of the marker in NHL. Bcl-6 was positive in 13.6% (6 of 44) of cases (11.1% of mantle cell lymphoma and 40% of diffuse large B-cell lymphoma) and its positivity implies a better disease course. Bcl-2 and Bcl-6 can be used as prognostic marker in NHL.
Keywords:
Bcl-2; Bcl-6; Non-Hodgkin’s lymphoma
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MDPI and ACS Style
Mahmoud, H.M.; Elsakhawy, Y.N. Significance of Bcl-2 and Bcl-6 Immunostaining in B-Non Hodgkin's lymphoma. Hematol. Rep. 2011, 3, e26. https://doi.org/10.4081/hr.2011.e26
AMA Style
Mahmoud HM, Elsakhawy YN. Significance of Bcl-2 and Bcl-6 Immunostaining in B-Non Hodgkin's lymphoma. Hematology Reports. 2011; 3(3):e26. https://doi.org/10.4081/hr.2011.e26
Chicago/Turabian StyleMahmoud, Hanan Mohamed, and Yasmin Nabil Elsakhawy. 2011. "Significance of Bcl-2 and Bcl-6 Immunostaining in B-Non Hodgkin's lymphoma" Hematology Reports 3, no. 3: e26. https://doi.org/10.4081/hr.2011.e26
