Open Access, Peer-reviewed
pISSN 2233-7385
eISSN 2233-7393
    Chonnam Med J. 2009 Dec;45(3):161-167. Korean.
    Published online Dec 10, 2009.
    https://doi.org/10.4068/cmj.2009.45.3.161
    Copyright © 2009 Chonnam National University Medical School
    Original Article

    Prevalence and Risk Factors for HIV-associated Peripheral Sensory Neuropathy in HIV-infected Adults in Daegu, Korea

    Hee-Young Hwang, Hyun-Ha Chang, Shin-Woo Kim, Seong Yeol Ryu,1 Hye-In Kim, Ga-Young Park, Yu-Jin Kwon, Jong-Myung Lee and Nung-Soo Kim
      • Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
      • 1Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
    • Corresponding author (Email: changhha@knu.ac.kr )
    Accepted September 18, 2009.

    Abstract

    Peripheral neuropathies complicate all stages of HIV infection and cause considerable morbidity and disability in HIV-infected individuals. The aim of this study was to describe the prevalence and risk factors of HIV-associated symptomatic distal sensory polyneuropathy (HIV-DSPN) in the HAART era in Daegu, Korea. HIV-infected adults visiting two tertiary teaching hospitals in Daegu during a 2-month period (October 2008 to November 2008) were screened for HIV-DSPN. HIV-DSPN was defined as being present if the patient had neuropathic symptoms or abnormal neurologic signs. Demographic, clinical, laboratory, and treatment data were collected, and statistical analysis was done. One hundred fifty patients (136 patients in Kyungpook National University Hospital and 14 patients in Dongsan Medical Center) were screened. The prevalence of HIV-DSPN was 16.0% (24/150). In the univariate analysis, the statistically significant risk factors for symptomatic peripheral sensory neuropathy were older age [40.6±9.4 years in the DSPN(-) group vs. 46.2±9.5 years in the DSPN(+) group, p=0.009], diagnosis of AIDS [odds ratio: 4.605 (95% CI: 1.305~16.256), p=0.011], and treatment of tuberculosis [odds ratio: 3.912 (95% CI: 1.352~11.317), p=0.015]. In the multivariate analysis, older age (odds ratio: 1.082, 95% CI: 1.024~1.143, p=0.005) and diagnosis of AIDS (odds ratio: 7.861, 95% CI: 1.330~46.452, p=0.023) were still significant risk factors. HIV-DSPN was not uncommon among ambulatory patients (16.0% prevalence) in Daegu, Korea, and more careful history taking and physical examination for HIV-DSPN should be performed in the management of older AIDS patients.

    Keywords
    HIV infections; AIDS; Neuropathy; Risk factors

    Figures

    Fig. 1
    The prevalence of HIV-associated DSPN in Daegu (DSPN; distal sensory polyneuropathy, KNUH; Kyungpook Natl. Univ. Hospital, DSMC; Dongsan Medical Center).

    Tables

    Table 1
    Baseline characteristics of 150 HIV infected patients from Kyungpook National University Hospital and Keimyung Dongsan Medical Center

    Table 2
    Univariate analysis of the comorbid diseases and opportunistic infections for HIV-associated DSPN

    Table 3
    Univariate analysis of the treatment exposure for HIV-associated DSPN

    Table 4
    Multivariate analysis of risk factors for HIV-associated DSPN

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    MeSH Terms
    Adult
    Antiretroviral Therapy, Highly Active
    HIV Infections
    Hospitals, Teaching
    Humans
    Korea
    Multivariate Analysis
    Neurologic Manifestations
    Peripheral Nervous System Diseases
    Physical Examination
    Polyneuropathies
    Prevalence
    Risk Factors
    Tuberculosis
    Metrics
    Share
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    Tables
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