Journal List > Tuberc Respir Dis > v.55(3) > 1062267

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Hahn, Moon, Chang, Choi, Shin, Kim, Chang, Kim, and Kim: A Case of the Bleomycin-Induced Bronchiolitis Obliterans Organizing Pneumonia
Case Report

Tuberculosis and Respiratory Diseases 2003; 55(3): 311-316.

Published online: 30 September 2003

DOI: https://doi.org/10.4046/trd.2003.55.3.311

A Case of the Bleomycin-Induced Bronchiolitis Obliterans Organizing Pneumonia

Chang Hoon Hahn, M.D.1, Jin Wook Moon, M.D.1, Jae Hyun Chang, M.D.1, Byoung Wook Choi, M.D.3, Dong Whan Shin, M.D.4, Se Kyu Kim, M.D.1, 2, Joon Chang, M.D.1, 2, Sung Kyu Kim, M.D.1, 2, Young Sam Kim, M.D.1, 2

1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

2Department of Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.

3Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul, Korea.

4Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Address for correspondence: Young Sam Kim, M.D. Department of Internal Medicine, Yonsei University College of Medicine, CPO BOX 8044, Seoul 120-752, Korea. Phone: 82-2-361-5394, Fax: 82-2-393-6884, ysamkim@yumc.yonsei.ac.kr

Copyright©2003. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

A 34-year-old man was admitted to our hospital due to fever and cough. He received the combination anti-cancer chemotherapy for testicular tumor, including bleomycin. The chest X-ray showed consolidation and ground glass opacity on the right upper lobe and subpleural areas of other lobes. This condition was initially misdiagnosed as a pneumonia, but consolidation did not disappear after antibiotics treatment. We performed transbronchial lung biopsy and bleomycin induced pulmonary toxicity was confirmed.
The bleomycin induced lung injury is the most common chemotherapeutically induced pulmonary disease. Bleomycin induced Bronchiolitis Obliterans Organizing Pneumonia(BOOP) is less common than interstitial pneumonitis and respond well to corticosteroid treatment.

Keywords: Bleomycin, Pulmonary toxicity, BOOP

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