In Vitro Controlled Release of Topically Applied Capsaicin from Silk Hydrogel: A Study Contributed to the Pain Relief System

Rui Jiang; Fang Zhang; Zhu Ping Yin; Shen Zhou Lu

doi:10.4028/www.scientific.net/MSF.815.332

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HomeMaterials Science ForumMaterials Science Forum Vol. 815In Vitro Controlled Release of Topically Applied...

In Vitro Controlled Release of Topically Applied Capsaicin from Silk Hydrogel: A Study Contributed to the Pain Relief System

Abstract:

The availability of a safety and efficient vehicle for pain relief system remains major challenge. The clinical applications of capsaicin are restricted by lacking a long-term drug delivery system The purpose of the present study is to control the release of topically applied capsaicin from silk fibroin hydrogel, all factors including proportions of silk fibroin, amount of capsaicin and penetration enhancer are studied. The capsaicin release behavior was measured by using x-ray fluorescence spectroscopy (XRF). X-ray diffraction (XRD) was used to investigate structure of the silk fibroin hydrogels. The results indicate that the silk can protect the capsaicin and also all factors involved influence the capsaicin release behavior. The release of the capsaicin may be controlled exactly by changing the factors involved. So the silk fibroin hydrogels make the capsaicin a promising pain relief drug used in clinic in the future.

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Periodical:

Materials Science Forum (Volume 815)

Pages:

332-335

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.815.332

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Online since:

March 2015

Authors:

Rui Jiang, Fang Zhang, Zhu Ping Yin, Shen Zhou Lu

Keywords:

Capsaicin, Delivery, Hydrogel, Pain Relief, Silk Fibroin

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