Fabrication of Bioactive Polycaprolactone by Incorporation of Apatite Nuclei

Hasnat Zamin; Tomoko Hiruta; Takeshi Yabutsuka; Shigeomi Takai

doi:10.4028/www.scientific.net/KEM.782.91

Paper Titles

Apatite-Forming Ability of Hydrophobicized Cellulose Nanofiber Imparted by Combination with Apatite Nuclei
p.65

Evaluation of Elution Behavior of Silver Ions from Silver-Containing Carbonate Hydroxyapatite Composites
p.72

Bioactivity Assessment of Apatite Nuclei-PVDF Composite Thin Films
p.78

Fabrication of Novel Hemostatic Film with Oxidized Cellulose and Sugar-Containing Hydroxyapatite
p.84

Fabrication of Bioactive Polycaprolactone by Incorporation of Apatite Nuclei
p.91

Fabrication of Hydroxyapatite/Cellulose Fiber Composite with Sheet-Like Structure
p.98

Preparation and Characterization of Ha/Gel/β-TCP Microspheres Composite Porous Scaffold
p.103

Effect of the Pore Structure of an Apatite-Fiber Scaffold on the Differentiation of P19.CL6 Cells into Cardiomyocytes
p.116

Preparation and Evaluation of Spray-Dried Nano-Hydroxyapatite/Saccharide Complex for Oral Administration
p.124

HomeKey Engineering MaterialsKey Engineering Materials Vol. 782Fabrication of Bioactive Polycaprolactone by...

Fabrication of Bioactive Polycaprolactone by Incorporation of Apatite Nuclei

Abstract:

When the pH or the temperature of a simulated body fluid is raised, fine particles of calcium phosphate are precipitated, which are named apatite nuclei (AN). In this study, we aimed to impart bioactivity to polycaprolactone by incorporating AN. AN-PCL composite films having different weight percentages of AN in PCL were fabricated by solution casting technique, using doctor blade method. Results showed that more than 20 wt.% AN-PCL films were fully covered with hydroxyapatite layer in three days soaking period in SBF.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Key Engineering Materials (Volume 782)

Pages:

91-97

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.782.91

Citation:

Cite this paper

Online since:

October 2018

Authors:

Hasnat Zamin, Tomoko Hiruta, Takeshi Yabutsuka, Shigeomi Takai

Keywords:

Apatite Nuclei, Bioactivity, Polycaprolactone, Simulated Body Fluid (SBF), Thin Film

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

References

[1] S. Weiner, H.D. Wagner, THE MATERIAL BONE: Structure-Mechanical function relation, Annu. Rev. Mater. Res. 28 (1998) 271-298.

DOI: 10.1146/annurev.matsci.28.1.271

Google Scholar

[2] L.L. Hench, J.M. Polak, Third-generation biomedical materials, Science, 295 (2002) 1014-1017.

DOI: 10.1126/science.1067404

Google Scholar

[3] N. Bölgen, Y.Z. Menceloglu, K. Acatay, I. Vargel, E. Piskin, In vitro and in vivo degradation of non-woven materials made of poly(epsilon-caprolactone) nanofibers prepared by electrospinning under different conditions, J. Biomater. Sci. Polym. Ed. 16 (2005).

DOI: 10.1163/156856205774576655

Google Scholar

[4] T. Kokubo, H. Kushitani, S. Sakka, T. Kitsugi, T. Yamamuro, Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W3., J. Biomed. Mater. Res. 24 (1990) 721-734.

DOI: 10.1002/jbm.820240607

Google Scholar

[5] T. Kokubo, H. Takadama, How useful is SBF in predicting in vivo bone bioactivity?, Biomaterials 27 (2006) 2907-2915.

DOI: 10.1016/j.biomaterials.2006.01.017

Google Scholar

[6] H. Takadama, T. Kokubo, In vitro evaluation of bone bioactivity, in: T. Kokubo (Eds.), Bioceramics and their clinical applications, Woodhead Publishing, Cambridge (2008)165-182.

DOI: 10.1533/9781845694227.1.165

Google Scholar

[7] ISO 23317: 2007, Implants for surgery - In vitro evaluation for apatite-forming ability of implant materials.

Google Scholar

[8] T. Yao, M. Hibino and T. Yabutsuka, U.S. patent 8,512,732. (2013), Japanese Patent 5,252,399. (2013).

Google Scholar

[9] E.C. Chen, T.M. Wu, Isothermal crystallization kinetics and thermal behavior of poly(ε caprolactone)/multi-walled carbon nanotube composites, Polym. Degrad. Staby. 92 (2007) 1009-1015.

DOI: 10.1016/j.polymdegradstab.2007.02.019

Google Scholar

[10] X. Chen, A. Nouri, Y. Li, J. Lin, P.D. Hodgson, C. Wen, Effect of Surface Roughness of Ti, Zr, and TiZr on Apatite Precipitation From Simulated Body Fluid, Biotechnol. Bioeng. 101 (2008) 378–387.

DOI: 10.1002/bit.21900

Google Scholar