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HomeJournal of Nano ResearchJournal of Nano Research Vol. 45Electrochemical Ultra-Low Detection of Isoniazid...

Electrochemical Ultra-Low Detection of Isoniazid Using a Salicylaldamine Functionalised G1-DAB-(NH₂)₄ Dendritic Sensor vs. UV-VIS Spectrophotometric Detection

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Abstract:

A poly(propyleneimine) based dendrimer was synthesised and successfully functionalised with a copper centre within its branches. The dendrimer and corresponding metallodendrimer were successfully characterised using FTIR, HR-TEM and HR-SEM in order to determine the effect of the inclusion of copper into the dendritic structure. The incorporation of copper caused crystallinity as revealed in the HR-TEM and a sheet-like morphology as shown in the HR-SEM images. The resulting metallodendrimer was then applied as an electrocatalytic platform for the sensing of a first line TB drug called isoniazid. This method was compared to a routine laboratory detection using UV-Vis and was found to be much more sensitive to trace amounts of isoniazid in solution. The electrochemical detection was found to have a limit of detection (LOD) of 0.233 nM compared to 11.47 nM using the Ultraviolet-visible spectroscopy method.

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Journal of Nano Research Vol. 45

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Periodical:

Journal of Nano Research (Volume 45)

Pages:

164-174

DOI:

https://doi.org/10.4028/www.scientific.net/JNanoR.45.164

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Online since:

January 2017

Authors:

Candice Rassie*, Juanita Van Wyk, Lindsay Wilson, Nomaphelo Ntshongontshi, Anovuyo Jonnas, Usisipho Feleni, Rachel Fanelwa Ajayi, Priscilla Baker, Emmanuel Iwuoha

Keywords:

Electrochemical Detection, HR-SEM, HR-TEM, Isoniazid, Metallodendrimer, Sensor, TB Drug, UV-VIS

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