Distribution & Access For Publication Downloads News About Us Contact Us
Paper Titles
Computation of the Effective Conductivity of Fibrous Composites with Imperfect Thermal Contact by Combination of Asymptotic Homogenization, Domain Decomposition and Finite Elements Methods
p.60
Analysis of Two Oil Spills in the Southern Brazilian Shelf, in the Years of 2012 and 2014
p.70
Regular and Irregular Wave Propagation Analysis in a Flume with Numerical Beach Using a Navier-Stokes Based Model
p.81
Acelerated Test Methods: Determining the Diffusion Coefficient of Concretes in the Saturated Condition
p.91
Inverse Stochastic Routine Combined to a Stepwise Modeling Approach in the Chromatographic Column Characterization Applied to Simulated Moving Bed-SMB Separation of Verapamil Enantiomers
p.101
Geometric Evaluation of Forced Convective Flows across an Arrangement of Four Circular Cylinders
p.110
An Automated Structure for Acquiring and Processing Sentinel-1 Data and its Applicability for Coastal Studies
p.122
Ship Movements’ Analysis in a Physical Scale Model
p.132
Numerical Study of the Effect of Reynolds Number and Aspect Ratio in Heat Transfer from Elliptical Tubes to Viscoplastic Fluids Employing Constructal Design
p.142

Inverse Stochastic Routine Combined to a Stepwise Modeling Approach in the Chromatographic Column Characterization Applied to Simulated Moving Bed-SMB Separation of Verapamil Enantiomers

Article Preview

Abstract:

Simulated Moving Bed (SMB) chromatographic processes for the enantiomers separation of the drug verapamil were evaluated through stepwise modeling approach. Predictions of the model were compared to the dispersive equilibrium model in the simulation of continuous separation process and validated with data taken for both compounds in a SMB experimental set-up. An inverse problem tool was associated to the chromatographic columns aiming at their characterization through the global mass transfer parameters using only the experimental residence times of each enantiomer. According to the study conducted, the proposed approach was shown to be a tool with a good potential to predict the chromatographic behavior of a sample in a test pulse, as well as the simulation of separation of a compound in SMB equipment despite minor discrepancies presented in the first work cycles of the SMB. Moreover, the approach can be easily implemented and applied in the analysis of the process.

You might also be interested in these eBooks
Transfer Phenomena in Fluid and Heat Flows II View Preview

Info:

Periodical:

Defect and Diffusion Forum (Volume 372)

Pages:

101-109

DOI:

https://doi.org/10.4028/www.scientific.net/DDF.372.101

Citation:

Cite this paper

Online since:

March 2017

Authors:

Anderson Luis Jeske Bihain*, Pedro Castro Menezes Xavier de Mello e Silva, Everton Mendes de Oliveira, Leandro Blass, Antônio José da Silva Neto, Leôncio Diógenes Tavares Câmara

Keywords:

Enantiomer, HPLC, Liquid Chromatography, Mass Transfer, Simulated Moving Bed

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

* - Corresponding Author

References

[1] R. W. M. Thompson and A. C. Mattjie. Remoção de corantes têxteis por adsorção utilizando carvão ativado obtido de materiais não convencionais. In Anais do III ENDICT), Toledo, PR, Brasil, (2011).

DOI: 10.17648/enemp-2022-159094

Google Scholar

[2] A. Mod. Adsorção de albumina de soro bovino em resinas trocadoras de íons. Master thesis, UNICAMP, (1996).

DOI: 10.47749/t/unicamp.1996.104816

Google Scholar

[3] Ferreira, I. C. S. Tratamento Terciário da Indústria de Laticínios Através da adsorção de Lactose em Argila Esmectítica. Master Thesis, São Paulo: USP, (2007).

DOI: 10.11606/d.3.2007.tde-06072007-140835

Google Scholar

[4] Gomes, P. M. A.; Figueiredo, R. M. F.; Queiroz, A. J. M. Revista Brasileira de Produtos Agroindustriais. Caracterização e Isotermas de Adsorção de Umidade da Polpa de Acerola em Pó. Vol. 4, pp.157-165, 2002. 4.

DOI: 10.15871/1517-8595/rbpa.v4n2p157-165

Google Scholar

[5] Edelar, L. C. Separação de Compostos Petroquímicos em Unidades de Leito Móvel Simulado. Ph.D. Dissertation Florianópolis: UFSC, (2003).

Google Scholar

[6] F. Wei, M. Li, F. Huang, M. Chen, H. Jiang, and Y. Zhao. A novel pseudo simulated moving bed with solvent gradient for ternary separations. Journal of Chromatography A, 1218: 2906–2911, (2011).

DOI: 10.1016/j.chroma.2011.03.001

Google Scholar

[7] Mun, S. Improving Performance of a Tandem Simulated Moving Bed Process for Sugar Separation by Making a Difference in the Adsorbents and the Column Lengths of the Two Subordinate Simulated Moving Bed Units. Journal of Chromatography A, pp.48-57, (2013).

DOI: 10.1016/j.chroma.2012.12.056

Google Scholar

[8] Long, N. V. D.; Lee, J. W.; Le, T. H.; Kim, J. I.; Koo, Y. M. Solvent-Gradient SMB to Separate O-xylene and p-xylene. Journal of Chemical Engineering, pp.1110-1119, (2010).

DOI: 10.1007/s11814-010-0475-1

Google Scholar

[9] Zaijun, L.; Xiulan, S.; Junkang, L. Ionic Liquid as Novel Solvent for Extraction and Separation in Analytical Chemistry. Applications and Perspectives, pp.154-180, (2011).

DOI: 10.5772/14250

Google Scholar

[10] O. Rbeida, B. Christiaens, PH. Hubert, D. Lubda, K. Boos, J. Crommen, and P. Chiap. Evaluation of a novel anionexchange restricted-access sorbent for on-line sample clean-up prior to the determination of acidic compounds in plasma by liquid chromatography. Journal of Chromatography A, 1030: 95–102, (2004).

DOI: 10.1016/j.chroma.2003.11.031

Google Scholar

[11] Broughton, D. B. 1961. US Patent US002985589, Simulated Moving Bed. USA, (1961).

Google Scholar

[12] L. D. T. Câmara. Stepwise model evaluation in simulated moving-bed separation of ketamine. Chemical Engineering Technology, 37: 301–309, 2014. DOI: 10. 1002/ceat. 201200193.

DOI: 10.1002/ceat.201200193

Google Scholar

[13] Gonçalves, C. V. (2008). Campinas: UNICAMP: Doctoral thesis.

Google Scholar

[14] A. L. J. Bihain. Phd thesis, IPRJ - UERJ, Nova Friburgo, RJ, Brasil, (2014).

Google Scholar

[15] R. F. Perna. Separação Cromatográfica dos Enantiômeros de Fármaco Verapamil em Processo Contínuo Multicolunas. Phd thesis, UNICAMP, Campinas, SP, Brasil, (2013).

DOI: 10.47749/t/unicamp.2013.911425

Google Scholar

[16] Bihain, A. L. J.; Silva Neto, A. J.; Câmara, L. D. T., Front Velocity approach to evaluate separation of enantiomers by Simulated Moving Bed process. Springer AISC book. 2014 (Submitted).

DOI: 10.5220/0005009400050011

Google Scholar

[17] D. Antos, A. Seidel-Morgenstern, Chem. Eng. Sci. 2001, 56, 6667.

Google Scholar

[18] V. R. Meyer, Practical High Performance Liquid Chromatography, John Wiley and Sons, New York (2004).

Google Scholar

[19] L.D.T. CÂMARA and A.J. Silva Neto. Inverse stochastic characterization of adsorption systems by a random restricted window (r2w) method. In International. Conference on Engineering Optimization (ENGOPT), Rio de Janeiro, RJ, Brasil, (2008).

Google Scholar

[20] SCHMIDT-TRAUB, H. Preparative Chromarography: of fine chemicals and pharmaceutical agents. Wheinheim, Germany: Wiley-VCH®, 2005, 485p.

Google Scholar

[21] Silva Junior, I. J.; Sartor, J. P.; Rosa, P. C. P., Santana, C.C. High-Performance Liquid Chromatographic Separation of Rolipram, Bupivacaine and Omeprazole Using a Tartardiamide-Based Stationary Phase Influence of Flow Rate and Temperature on the Enantioseparation. Journal of Chromatography A. Vol. 1162, pp.97-102, (2007).

DOI: 10.1016/j.chroma.2007.07.008

Google Scholar

[22] ROSA, PAULO CÉSAR PIRES. Estudo da separação cromatográfica dos enantiômeros do omeprazol em fase estacionária quiral Kromasil CHI-TBB (0, 0-Bis[4-terc-butilbenzoil]-N, Ndialil- L-tartadiamida). Master Thesis, UNICAMP, (2005).

DOI: 10.47749/t/unicamp.2005.338352

Google Scholar

[23] Macherey-Nagel. Guia para colunas cromatográficas, pp.62-66, (2000).

Google Scholar

Scientific.Net is a registered brand of Trans Tech Publications Ltd
© 2024 by Trans Tech Publications Ltd. All Rights Reserved