Antibacterial Nanocoatings for Ocular Applications

Francesco Baino; Sergio Perero; Marta Miola; Monica Ferraris

doi:10.4028/www.scientific.net/AST.102.24

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HomeAdvances in Science and TechnologyAdvances in Science and Technology Vol. 102Antibacterial Nanocoatings for Ocular Applications

Antibacterial Nanocoatings for Ocular Applications

Abstract:

Bacterial issues in ophthalmic applications, with particular reference to postoperative infection of ocular implants, cause significant problems that often require additional, stressful and expensive treatments for the patients. In this work we applied silver-containing antibacterial costings on two kinds of polymeric ocular devices, i.e. silicone scleral buckles for retinal detachment surgery and poly(methyl methacrylate) artificial eyes for enucleated patients. The coatings (thickness around 50 nm), constituted by silver nanoclusters embedded in a silica matrix, were produced by RF co-sputtering and investigated by SEM and EDS. The antibacterial effect of the coating was confirmed by the in vitro formation of an inhibition halo against Staphylococcus aureus, which is one of the most common pathogens involved in ocular infections. The approach proposed in this study for treating implant-related ocular infections can have a significant impact in the field of ophthalmic biomaterials, suggesting a valuable alternative to the administration of antibiotics that may become ineffective towards resistant bacterial strains.

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Periodical:

Advances in Science and Technology (Volume 102)

Pages:

24-28

DOI:

https://doi.org/10.4028/www.scientific.net/AST.102.24

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Online since:

October 2016

Authors:

Francesco Baino*, Sergio Perero, Marta Miola, Monica Ferraris

Keywords:

Antimicrobial, Coating, Ophthalmic Biomaterial, Silver, Sputtering

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* - Corresponding Author

References

[1] S. Karsloglu, D. Serin, I. Simsek, S. Ziylan, Implant infection in porous orbital implants, Ophthal. Plast. Reconstr. Surg. 22 (2006) 461-466.

DOI: 10.1097/01.iop.0000248156.41020.94

Google Scholar

[2] F. Baino, Scleral buckling biomaterials and implants for retinal detachment surgery, Med. Eng. Phys. 32 (2010) 945-956.

DOI: 10.1016/j.medengphy.2010.07.007

Google Scholar

[3] D.M. Moshfeghi, A.A. Moshfeghi, P.T. Finger, Enucleation, Surv. Ophthalmol. 44 (2000) 277-301.

DOI: 10.1016/s0039-6257(99)00112-5

Google Scholar

[4] F. Baino, S. Perero, S. Ferraris, M. Miola, C. Balagna, E. Verné, C. Vitale-Brovarone, A. Coggiola, D. Dolcino, M. Ferraris, Biomaterials for orbital implants and ocular prostheses: overview and future prospects, Acta Biomater. 10 (2014).

DOI: 10.1016/j.actbio.2013.12.014

Google Scholar

[5] NCCLS M2-A9. Performance Standards for Antimicrobial Disk Susceptibility Tests. Approved Standard. 9th Edition.

Google Scholar

[6] C.C. Chuang, C.H. Hsiao, H.Y. Tan, D.H.K. Ma, K.K. Lin, C.J. Chang, Y.C. Huang, Staphylococcus aureus ocular infection: methicillin-resistance, clinical features, and antibiotic susceptibilities, Plos One 8 (2012) e42437.

DOI: 10.1371/journal.pone.0042437

Google Scholar

[7] F. Baino, S. Ferraris, M. Miola, S. Perero, E. Verné, A. Coggiola, D. Dolcino, M. Ferraris, Novel antibacterial ocular prostheses: proof of concept and physico-chemical characterization, Mater. Sci. Eng. C 60 (2016) 467-474.

DOI: 10.1016/j.msec.2015.11.075

Google Scholar

[8] W.K. Jung, H.C. Koo, K.W. Kim, S. Shin, S.H. Kim, Y.H. Park, Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli, Appl. Environ. Microbiol. 74 (2008) 2171-2178.

DOI: 10.1128/aem.02001-07

Google Scholar