Preparation and Characterization of Shellac Fiber as a Novel Material for Controlled Drug Release

Thanachod Thammachat; Pornsak Sriamornsak; Manee Luangtana-Anan; Jurairat Nunthanid; Chutima Limmatvapirat (1); Sontaya Limmatvapirat

doi:10.4028/www.scientific.net/AMR.152-153.1232

Paper Titles

A Statistical Constitutive Model for the Strength of Brittle Fiber at Different Strain Rates
p.1213

Experimental Investigation of Microsegregation in Low Frequency Electromagnetic Casting of Al-4.5%Cu Binary Alloy
p.1217

Hydrothermal Synthesis and Characterization of Single-Crystal Lead Titanate Nanoflakes
p.1222

Mechanical Wear of SnO₂-C Morph-Genetic Composite Materials
p.1227

Preparation and Characterization of Shellac Fiber as a Novel Material for Controlled Drug Release
p.1232

Synthesis of Star-Shaped PLA via Direct Melt Polycondensation: 1. Using L-LA as Starting Material
p.1236

The Effect of Melt-Spinning Technology on the Degradation of Poly(Glycolic Acid) Fiber In Vitro
p.1240

The Fracture Research of Hexagonal Duralumin Nut
p.1244

Influence of Citric Acid on the Formation of Hydroxyapatite Powders by Using Ca(NO₃)₂-P₂O₅ Ethanol Solution System
p.1248

HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 152-153Preparation and Characterization of Shellac Fiber...

Preparation and Characterization of Shellac Fiber as a Novel Material for Controlled Drug Release

Abstract:

The aim of this study was to investigate the effect of electrospinning process on the physical properties of fibers made from shellac. Electrospun shellac fiber was prepared by dissolving shellac in ethanol and then transferred to the electrospinning system. The influences of process parameters; including electric field voltage, tip to collector gap, feeding rate and concentration of shellac solutions; on the spinnability and properties of obtained shellac fibers were elucidated. The result demonstrated that micro-nano fibers of shellac were easily formed after spinning. The concentration of shellac solution was a crucial parameter that determined the spinnability. The electro-sprayed particles of shellac were achieved at the concentration of 35% w/w and lower while the electrospun fibers was formed in the concentration range of 40-45 % w/w. SEM pictures demonstrated that the beaded fiber structure obtained at 40-43% w/w was changed to the continuous fiber structure at 45% w/w. The diameter of fiber showed a tendency to increase while the size distribution of diameter was narrower as increasing voltage. The other optimized electrospinning parameters including feeding rate, tip to collector gap were 0.5-2 ml/h and 15-20 cm, respectively. In conclusion, the study demonstrated the critical parameters that determined the properties of required fibers. The knowledge gained should support the development of the drug incorporated electrospun shellac fiber in near future.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Advanced Materials Research (Volumes 152-153)

Pages:

1232-1235

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.152-153.1232

Citation:

Cite this paper

Online since:

October 2010

Authors:

Thanachod Thammachat, Pornsak Sriamornsak, Manee Luangtana-Anan, Jurairat Nunthanid, Chutima Limmatvapirat (1), Sontaya Limmatvapirat

Keywords:

Controlled Drug Release, Electro-Spinning, Fiber, Optimization, Shellac

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

References

[1] S. Ramakrishna, F. Kazutoshi, T. Wee-Eong, L. Teik-Cheng, M. Zuwei, An introduction to electrospinning and nanofibers, World Scientific Publishing, Singapore, (2005).

Google Scholar

[2] S. Limmatvapirat, C. Limmatvapirat, M. Luangtana-Anan, J. Nunthanid, T. Oguchi, Y. Tozuka, K. Yamamoto, S. Puttipipatkhachorn, Modification of physicochemical and mechanical properties of shellac by partial hydrolysis, Int. J. Pharm., 278 (2004).

DOI: 10.1016/j.ijpharm.2004.02.030

Google Scholar

[3] S. Limmatvapirat, D. Panchapornpon, C. Limmatvapirat, J. Nunthanid, M. Luangtana-Anan, S. Puttipipatkhachorn, Formation of shellac succinate having improved enteric film properties through dry media reaction, Eur. J. Pharm. Biopharm., 70 (2008).

DOI: 10.1016/j.ejpb.2008.03.002

Google Scholar

[4] S. Zhao, X. Wu, L. Wang, Y. Huang, Electrospinning of ethyl-cyanoethyl cellulose/tetrahydrofuran solutions, J. Appl. Polym. Sci., 91 (2004) 242-246.

DOI: 10.1002/app.13196

Google Scholar

[5] S. Zhang, W.S. Shim, J. Kim, Design of ultra-fine nonwovens via electrospinning of Nylon 6: Spinning parameters and filtration efficiency, Materials & Design, 30 (2009) 3659-3666.

DOI: 10.1016/j.matdes.2009.02.017

Google Scholar