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In Vitro Response and Adhesive Strength of Titanium and Hydroxyapatite Bilayer-Films on Polyetheretherketone Substrate
Abstract:
In order to impart both osseointegration and osteoconduction characteristics onto extruded pure polyetheretherketone (PEEK) for use as an artificial bone material, the surface of the PEEK was sputter-coated with a thin bilayer-film consisting of a commercially pure titanium (Ti) layer with a thickness of 90 nm and a hydroxyapatite layer with a thickness of 200 nm derived from simulated body fluid (SBF-HA). A specimen of PEEK coated only with Ti was used in peeling tests to determine the adhesive strength of the interface between the two materials, which was found to be 2.55 ± 0.45 MPa. Tensile tests were also carried out, and it was found that no exfoliation of the Ti film occurred until an ultimate strain of 129% was reached. In a cell culture test using mouse osteoblast on the bilayer-coated PEEK, cell proliferation following 168 h of culturing was 1.3 times higher on the SBF-HA than on synthetic hydroxyapatite, and 2.4 times higher than that on the Ti-coated PEEK. In addition, the proliferation on the Ti-coated PEEK was 2.1 times higher than that on uncoated PEEK.
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Periodical:
Pages:
51-55
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Online since:
September 2013
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