Internal Diffusion of Biocompatible Polymer-Coated Inorganic Nanoparticles in Mice

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Abstract:

In this study, we succeeded in preparation and characterization of two types of biocompatible polymer-coated inorganic nanoparticles (cupper and silicone oxide). As a biocompatible polymer, gelatin and poly(lactic acid) were used. For determination of their biodistribution, the obtained particles were administered to mice through the tail vein. After administration, the particles in some organs were determined with energy-dispersed X-ray spectrometer. The cupper nanoparticles were observed in the lung and kidney, while the silica particles were in the lung, liver and spleen. The distribution behaviors were quite different from non-polymer coated nanoparticles

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Periodical:

Key Engineering Materials (Volumes 493-494)

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752-756

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Online since:

October 2011

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[1] G. Hodes, When small is different: Some recent advances in concepts and applications of nanoscale phenomena, Adv. Mater., 19, (2007) 639-655.

DOI: 10.1002/adma.200601173

Google Scholar

[2] C. Burda, X. Chen, R. Narayanan, and M.A. El-Sayed, Chemistry and properties of nanocrystals of different shapes, Chem. Rev., 105, (2005) 1025-1102.

DOI: 10.1021/cr030063a

Google Scholar

[3] N. Toshima, and T. Yonezawa, Bimetallic nanoparticles - novel materials for chemical and physical applications, New J. Chem., 22, (1998) 1179-1201.

DOI: 10.1039/a805753b

Google Scholar

[4] M.J. Mulvihill, XY Ling, J. Henzie, P.D. Yang, Anisotropic Etching of Silver Nanoparticles for Plasmonic Structures Capable of Single-Particle SERS, J. Am. Chem. Soc., 132 (2010) 268-274.

DOI: 10.1021/ja906954f

Google Scholar

[5] A. Gopinath, S.V. Boriskina, B.M. Reinhard, L. Dal Negro, Deterministic aperiodic arrays of metal nanoparticles for surface-enhanced Raman scattering (SERS), Opt. Express, 17, (2009) 3741-3753.

DOI: 10.1364/oe.17.003741

Google Scholar

[6] G. Zoriniants, W.L. Barnes, Fluorescence enhancement through modified dye molecule absorption associated with the localized surface plasmon resonances of metallic dimmers, New J. Phys., 10, (2008) 10500201-12.

DOI: 10.1088/1367-2630/10/10/105002

Google Scholar

[7] Y. Lee, J-r. Choi, K.J. Lee, N.E. Stott, and D. Kim, Large-scale synthesis of copper nanoparticles by chemically controlled reduction for applications of inkjet-printed electronics, Nanotechnology, 19 (2008) 41560401-07.

DOI: 10.1088/0957-4484/19/41/415604

Google Scholar

[8] T. Yonezawa, S. Takeoka, H. Kishi, K Ida, and M. Tomonari, The preparation of copper fine particle paste and its application as the inner electrode material of a multilayered ceramic capacitor, Nanotechnology, 19 (2008) 14570601-05.

DOI: 10.1088/0957-4484/19/14/145706

Google Scholar

[9] F. Watari, N. Takashi, A. Yokoyama, M. Uo, T. Akasaka, Y. Sato, S. Abe, Y. Totsuka, and K. Tohji, Material nanosizing effect on living organisms: non-specific, biointeractive, physical size effects, J. Royal Soc. Interface, 6 (2009) S371-S388.

DOI: 10.1098/rsif.2008.0488.focus

Google Scholar

[10] T. Yonezawa, A. Hyono, and N. Nishida, Detailed investigation of the reduction process of cupric oxide (CuO) to form metallic copper fine particles with a unique diameter, J. Mater. Sci. 45 (2010) 6433-6439.

DOI: 10.1007/s10853-010-4728-5

Google Scholar

[11] T. Yonezawa, N. Nishida, and A. Hyono, One-pot preparation of antioxidized copper fine particles with a unique structure by chemical reduction at room temperature, Chem. Lett., 39 (2010) 548-549.

DOI: 10.1246/cl.2010.548

Google Scholar

[12] S. Abe, C. Koyama, M. Esaki, T. Akasaka, M. Uo, Y. Kuboki, M. Morita, and F. Watari, In vivo internal diffusion of several inorganic microparticles through an oral administration, Bio-Med. Mater. Eng., 19 (2009) 221-229.

DOI: 10.3233/bme-2009-0584

Google Scholar

[13] S. Abe, C. Koyama, M. Uo, T. Akasaka, Y. Kuboki and F. Watari, Time-dependence and visualization of TiO2 and Pt particle biodistribution in mice, J. Nanosci. Nanotech., 9, (2009) 4988-4991.

DOI: 10.1166/jnn.2009.1281

Google Scholar

[14] S. Abe, T. Yonezawa, T. Akasaka, M. Uo, F. Uchida, and F. Watari, Observation of Biodistribution of Indium-Tin Oxide Nanoparticles in mice, Nano Biomedicine, 1, (2009) 70-74.

Google Scholar

[15] S. Abe, N. Iwadera, M. Mutoh, C. Koyama, M. Esaki, T. Akasaka, M. Uo, M. Morita, Y. Kuboki, K. Haneda, Y. Yawaka, F. Uchida, T. Yonezawa, and F. Watari, Observation of internal distribution behavior of micro/nano-sized ceramics and metal particles in mice, Bioceram. Develop. Appli., 1, (2010).

DOI: 10.4303/bda/d110134

Google Scholar

[16] S. Abe, T. Kiba, K. Hosokawa, S. Nitobe, T. Hirota, H. Kobayashi, T. Akasaka, M. Uo, Y. Kuboki, S. -I. Sato, F. Watari, I. D. Rosca, Photophysical characterization of cumarin doped poly(lactic acid) micro particles and its fabrication for bioimaging, J. Electron Spectroscop. Related Phenomen., 181 (2010).

DOI: 10.1016/j.elspec.2010.04.002

Google Scholar