Characterization and Synthesis of a Betaxolol Hydrochloride Intermediate

Feng Ying Xu; Gui Zhen Fang

doi:10.4028/www.scientific.net/AMR.652-654.770

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 652-654Characterization and Synthesis of a Betaxolol...

Characterization and Synthesis of a Betaxolol Hydrochloride Intermediate

Abstract:

In this paper, a new method was developed to synthesize betaxolol hydrochloride intermediate (1-[4-(2-Hydroxyethyl) phenoxy]-2, 3-epoxypropane). Based on the acidity difference of phenolic hydroxyl and alcoholic hydroxyl in p-hydroxyphenylethyl alcohol, the betaxolol hydrochloride intermediate was synthesized by selective A.W.Williamson etherification between p-hydroxyphenylethyl alcohol and epichlorohydrin in 18% potassium carbonate-acetone alkalescent solution. The molar ratio of p-hydroxyphenylethyl alcohol and epichlorohydrin was fixed at 1:1.7. FTIR and HPLC analysis revealed that the product purity reached 96% and the yield was 68.18%. This method simplified the synthetic process of betaxolol hydrochloride, which would also result in higher yield and purity of betaxolol hydrochloride products.

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Periodical:

Advanced Materials Research (Volumes 652-654)

Pages:

770-773

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.652-654.770

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Online since:

January 2013

Authors:

Feng Ying Xu, Gui Zhen Fang

Keywords:

1-[4-(2-Hydroxyethyl) Phenoxy]-2, 3-Epoxypropane, Betaxolol Hydrochloride, Epichlorohydrin, P-Hydroxyphenylethyl Alcohol

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