The effect of differences in the type of restoration and adhesive resin cement system on the bonding of CAD/CAM ceramic restoration after cyclic loading was examined quantitatively and qualitatively. Seventy-two human maxillary first molars were divided into three restoration groups: MOD-inlay, MODP-onlay, and crown. Immediate dentin sealing was applied to the exposed dentin of all prepared specimens. The 24 specimens of each restoration group were further divided into another three groups, and a different adhesive resin cement system was applied to each group for cementation. All restoratives were fabricated from feldspathic-ceramic-blocks and cemented with each adhesive resin cement system according to the manufacturer’s instructions. The microtensile bond-strength was measured after cyclic loading and was not significantly affected by differences in the type of restoration or adhesive resin cement system. However, the type of restorations and adhesive resin cement systems did show significant differences in terms of the bonding reliability.