pISSN 2093-2340   eISSN 2092-6448
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    Infect Chemother. 2012 Oct;44(5):372-376. Korean.
    Published online Oct 31, 2012.
    https://doi.org/10.3947/ic.2012.44.5.372
    Copyright © 2012 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy
    Original Article

    A Clinical features of Severe Adenovirus Pneumonia among Members of the Korea Military: A Case Series

    Jung Yeon Heo,1 Hye Kang Kim,1 Yong Jun Cha,2 Ji Eun Lee,1 Young Soo Shim,1 and Kang-Won Choe1
      • 1Department of Internal Medicine, Armed Forces Capital Hopital, Sungnam, Korea.
      • 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
    • Correspondence to Kang-Won Choe, M.D. Department of Internal Medicine, Armed Forces Capital Hospital, 2 Gil 66 Ho Yul-dong, Bundang-Gu, Sungnam-si, Kyunggi-do 463-040, Korea. Tel: +82-31-725-6315, Fax: +82-31-706-0987, Email: choekw@snu.ac.kr
    Received June 07, 2012; Revised August 06, 2012; Accepted August 10, 2012.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Background

    Adenoviral diseases generally present as self-limiting upper respiratory illnesses. However, in some cases, adenovirus can cause fatal outcomes, even in healthy adults. Severe pneumonia caused by adenovirus in young soldiers at basic military training sites have been reported.

    Materials and Methods

    We conducted a retrospective review of the medical records of patients with pneumonia who were hospitalized in the Intensive Care Unit of the Armed Forces Capital Hospital between January 2011 and March 2012.

    Results

    Nine patients with pneumonia who required ventilator treatment were analyzed. Adenovirus was proved to be the causative agent of the illness in six out of nine patients, three of whom died due to severe adenoviral pneumonia or adenovirus-related illness. Among these six patients, three were military trainees. Clinical features were characterized by fever (100%) and cough (100%). Other important findings included thrombocytopenia (83.3%), leukopenia (66.6%), and radiologically lobar consolidation (66.7%).

    Conclusions

    Adenovirus appeared to be the most important pathogen of young Korean soldiers, particularly among military trainees with severe pneumonia requiring mechanical ventilation. Outbreak surveillance for adenovirus associated illness is necessary.

    Keywords
    Adenovirus; Severe pneumonia; Military personnel

    Figures

    Figure 1
    Serial Chest X-ray of Case No. 2 on the (A) 1st hospital day, (B) 3rd hospital day, and (C) 5th hospital day, and (D) chest CT scan on the 5th hospital day: Despite antibiotics and antiviral treatment, pneumonia on the right lung field showed rapid deterioration.

    Tables

    Table 1
    Characteristics, Clinical Feature and Outcome of Patients with Severe Adenovirus Pneumonia

    Table 2
    Laboratory Values and Radiological Findings of Six Pneumonia Patients on Admission to Intensive Care Unit

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    MeSH Terms
    Adenoviridae
    Adult
    Arm
    Cough
    Fatal Outcome
    Fever
    Humans
    Intensive Care Units
    Korea
    Leukopenia
    Medical Records
    Military Personnel
    Pneumonia
    Respiration, Artificial
    Retrospective Studies
    Thrombocytopenia
    Ventilators, Mechanical
    Metrics
    Share
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