Hepatic Amino Acid-Degrading Enzyme Expression Is Downregulated by Natural and Synthetic Ligands of PPARα in Rats1, 2, 3
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Abbreviations
AADE
amino acid-degrading enzyme
AP
activator protein
CPT-1
carnitine palmitoyltransferase-1
HAL
histidine ammonia lyase
PKA
protein kinase A
PKC
protein kinase C
PPRE, PPAR
responsive element
RXR
retinoid X receptor
SDH
serine dehydratase
TAT
tyrosine aminotransferase
6-C
control rats fed 6% casein diet
6-Wy
rats fed 6% casein diet with 0.1% Wy 14643
20-C
control rats fed 20% casein diet
20-Wy
rats fed 20% casein diet with 0.1% Wy 14643
50-C
control rats fed 50% casein diet
50-Wy
rats fed 50% casein diet with 0.1% Wy 14643
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Supported by Consejo Nacional de Ciencia y Tecnologia, México grant no. 41799-M.
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Author disclosures: G. Alemán, V. Ortiz, A. V. Contreras, G. Quiroz, G. Ordaz-Nava, E. Langley, N. Torres, and A. R. Tovar, no conflicts of interest.
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Supplemental Table 1 and Figure 1 are available from the “Online Supporting Material” link in the online posting of the article and from the same link in the online table of contents at http://jn.nutrition.org.
Copyright © 2013 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.