Abstract
The present study aims to investigate experimentally and theoretically thermal ablation in soft tissues by using high intensity focused ultrasound (HIFU) to assess tissue damage during HIFU thermotherapy. The HIFU field was calculated by solving the axisymmetric Khokhlov-Zabolotskaya-Kuznetsov equation from the frequency-domain perspective. The temperature field was calculated by solving Pennes’ bioheat transfer equation, and the thermal dose required to create a thermal lesion was calculated by using the thermal dose formula based on the thermal dose of a 240-min exposure at 43 °C. In order to validate the simulation results, we performed thermal ablation experiments in a tissue-mimicking phantom and ex-vivo porcine liver for two different HIFU source conditions by using a 1.1-MHz, single-element, spherically focused HIFU transducer. The small difference between the measured and the predicted lesion sizes suggests that the implementation of the numerical model used here should be modified to iteratively allow for temperature-dependent changes in the physical properties of tissues.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. R. Bailey, V. A. Khokhlova, O. A. Sapozhnikov, S. G. Kargl and L. A. Crum, Acoust. Phys. 49, 369 (2003).
C. W. Huang, M. K. Sun, B. T. Chen, J. Shieh, C. S. Chen and W. S. Chen, Ultrason. Sonochem. 27, 456 (2015).
J. Huang, R. G. Holt, R. O. Cleveland and R. A. Roy, J. Acoust. Soc. Am. 116, 2451 (2004).
V. A. Khokhlova, M. R. Bailey, J. A. Reed, B. W. Cunitz, P. J. Kaczkowski and L. A. Crum, J. Acoust. Soc. Am. 119, 1834 (2006).
J. E. Soneson, in Proceedings of the 8th International Symposium on Therapeutic Ultrasound (New York, 2009).
M. Pennes, J. Appl. Physiol. 1, 93 (1948).
K. I. Lee and M. J. Choi, Jpn. J. Appl. Phys. 48, 027003 (2009).
S. Howard, J. Yuen, P. Wegner and C. I. Zanelli, in Proceedings of the IEEE Ultrasonics Symposium (Honolulu, 2003).
S. R. Guntur and M. J. Choi, Ultrasound Med. Biol. 40, 2680 (2014).
S. Qiao, E. Jackson, C. C. Coussios and R. O. Cleveland, J. Acoust. Soc. Am. 140, 2039 (2016).
K. I. Lee, I. B. Sim, G. S. Kang and M. J. Choi, Mod. Phys. Lett. B 22, 803 (2008).
M. J. Choi, S. R. Guntur, K. I. Lee, D. G. Paeng and A. Coleman, Ultrasound Med. Biol. 39, 439 (2013).
S. R. Guntur and M. J. Choi, Ultrasound Med. Biol. 41, 806 (2015).
S. R. Guntur, K. I. Lee, D-G. Paeng, A. J. Coleman and M. J. Choi, Ultrasound Med. Biol. 39, 1771 (2013).
R. G. Holt and R. A. Roy, Ultrasound Med. Biol. 27, 1399 (2001).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lee, K.I. Simulation and Measurement of Thermal Ablation in a Tissue-Mimicking Phantom and Ex-Vivo Porcine Liver by Using High Intensity Focused Ultrasound. J. Korean Phys. Soc. 73, 1289–1294 (2018). https://doi.org/10.3938/jkps.73.1289
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.3938/jkps.73.1289