E-cadherin might be a stage-dependent modulator in aggressiveness in pancreatic cancer cells

Authors

ESRA AYDEMİR ÇOBAN
DİDEM TECİMEL
EZGİ KAŞIKCI
ÖMER FARUK BAYRAK
FİKRETTİN ŞAHİN

DOI

10.3906/biy-1912-60

Abstract

Pancreatic ductal adenocarcinoma (PDAC) pathology is known for its uncontrollable progress due to highly invasive characteristics and refractory behavior against existing chemotherapies. The aberrant expression of CDH1 (expresses the protein E-cadherin) is associated with increased overall survival in various cancers, however, E-cadherin expression in PDAC progression has remained elusive. We investigated the impact of exogenously elevated E-cadherin levels on the tumorigenicity of transduced low grade and metastatic PDAC cell lines, Panc-1 and AsPC-1, respectively. Constitutive expression of E-cadherin promoted a more hybrid E/M state in AsPC-1 cells, while it was associated with the acquisition of a more epithelial-like state in Panc1 cells. Our study suggests that E-cadherin may play differential roles in determining the metastatic characteristics of primary and metastatic pancreatic cancer cells.

Keywords

Panc-1, AsPC1, E-cadherin, CRISPR/dCas9 activation, pancreas cancer

First Page

230

Last Page

237

Recommended Citation

ÇOBAN, ESRA AYDEMİR; TECİMEL, DİDEM; KAŞIKCI, EZGİ; BAYRAK, ÖMER FARUK; and ŞAHİN, FİKRETTİN (2020) "E-cadherin might be a stage-dependent modulator in aggressiveness in pancreatic cancer cells," Turkish Journal of Biology: Vol. 44: No. 5, Article 2. https://doi.org/10.3906/biy-1912-60
Available at: https://journals.tubitak.gov.tr/biology/vol44/iss5/2