E-cadherin and associated molecules in the invasion and progression of prostate cancer.

Davies,G; Jiang,W G; Mason,M D

doi:10.3892/or.5.6.1567

E-cadherin and associated molecules in the invasion and progression of prostate cancer.

Authors:
- G Davies
- W G Jiang
- M D Mason
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Affiliations: Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff CF4 4XN, UK.
Published online on: November 1, 1998 https://doi.org/10.3892/or.5.6.1567
Pages: 1567-1643

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Abstract

Prostatic carcinoma is the most common type of male cancer found in the Western world and its distant metastasis becomes a life threatening event in tumour bearing patients. However, the biology of prostate cancer and metastasis is poorly understood. We review the progress made in the last decade on the molecular and cellular biology of cell-cell adhesion molecules in the invasion and progression of prostate cancer, with emphasis being placed on E-cadherin and its associated molecules.