光动力疗法(PDT)是一种联合利用光敏剂、光和氧分子,通过光动力反应选择性治疗恶性肿瘤和良性疾病的微创疗法。光源作为PDT的三大关键要素之一,其发光波长、照光方式以及剂量直接决定PDT疗效。针对临床治疗对光源的性能需求,探讨了发光二极管(LED)作为PDT光源的技术优势。深入介绍了LED阵列光源,以及用于发展可穿戴式、可植入式新型PDT光源的有机LED、量子点LED和无线驱动LED的研究进展。全面总结了LED在离体细胞、活体动物以及临床PDT等方面的应用现状。研发波长可切换的多波长LED并实现照光区域和剂量的实时调控是未来智能个性化PDT光源的发展趋势。

Photodynamic therapy (PDT) is a minimally invasive therapeutic modality that can selectively treat malignant and benign diseases by using a combination of photosensitizers, light, and oxygen molecules. The light source is one of the three key elements of PDT, and its emission wavelength, irradiation method, and dose directly determine the efficiency of PDT. According to the required performances of light sources for clinical treatment, the technical advantages of light-emitting diode (LED) as light source in PDT applications are discussed. The LED array light source, and the development of wearable and implantable novel PDT light sources based on the organic LED, quantum dot LED, and wireless powered LED are introduced in depth. The application status of LED in isolated cells, live animals, and clinical PDT is summarized comprehensively. The development of LEDs with tunable emission wavelengths and the real-time adjustment of the illumination area and dose are the future development trends of intelligent and personalized PDT light sources.