医学利用のための18F-2-デオキシ-2-フルオロ-D-グルコース (18FDG) の合成

入江 俊章; 井戸 達雄; 福士 清; 岩田 錬; 魚路 益男; 玉手 和彦; 山崎 統四郎; 樫田 義彦

doi:10.3769/radioisotopes.31.11

Aspects of the Preparation of ¹⁸F-2-deoxy-2-fluoro-_D-glucose (¹⁸FDG) for Medical Use

Toshiaki IRIE, Tatsuo IDO, Kiyoshi FUKUSHI, Ren IWATA, Masuo UOJI, Kazuhiko TAMATE, Toshio YAMASAKI, Yoshihiko KASHIDA

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Keywords: fluorine-18, fluorine-18-2-deoxy-2-fluoro-D-glucose, radiopharmaceuticals, labeled compounds

JOURNAL FREE ACCESS

1982 Volume 31 Issue 1 Pages 11-15

DOI https://doi.org/10.3769/radioisotopes.31.11

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Abstract

Fluorine-18-2-deoxy-2 fluoro-D-glucose (¹⁸FDG) for medical use had been prepared with the attention regarding radiochemical yield and purity, specific activity and quality control.
More than four ¹⁸F-by-products in ¹⁸F-adducts from the reaction of triacetyl glucal with ¹⁸F₂ were detected by the autoradiography of thin layer plates in which two by-products could not be perfectly removed by a column chromatography, and selective collection of the eluate gave ¹⁸FDG with the purity of 96.7% as an average in 12 runs. At end of synthesis (EOS) 259-925 MBq (7-25 mCi) of a sterilized, isotonic solution of ¹⁸FDG was obtained with the specific activity of 629-851 MBq (17-23 mCi) /mg at end of bombardment (EOB) after preparation time of 3-3.5 hr, in which bacteria and pyrogen were not detected.

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