Abstract
Rats with cannulas implanted into either the nucleus accumbens or the interventricular foramen were handled or handled and injected with 0, 20, 50, 80, or 1,000 ng of ACTH1–24 and then were observed for 1 h afterwards in small testing chambers. Excessive grooming was displayed in animals that had received 80 and 1,000 ng into the nucleus accumbens, but only the 1,000-ng dose was effective in eliciting excessive grooming in animals with intraventricular injections. The excessive grooming found after the 80-ng dose of ACTH in the nucleus accumbens was similar in amount and time course to that observed when 1,000 ng was injected into the ventricular system. The results indicate that the nucleus accumbens is an effective site for ACTH1–24 as it relates to excessive grooming.
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References
Beckstead, R. M. Convergent prefrontal and nigral projections to the striatum of the rat. Neuroscience Letters, 1979, 12, 59–64.
Brakkee, J. H., Wiegant, V. M., & Gispen, W. H. A simple technique for rapid implantation of a permanent cannula with the rat brain ventricular system. Laboratory Animal Science, 1979, 29, 78–81.
Colbern, D., Isaacson, R. L., Bohus, B., & Gispen, W. H. Limbic-midbrain lesions and ACTH-induced excessive grooming. Life Sciences, 1911, 21, 393–402.
Colbern, D., Isaacson, R. L., Green, E. J., & Gispen, W. H. Repeated intraventricular injections of ACTH1-24: The effects of home or novel environments on excessive grooming. Behavioral Biology, 1978, 23, 381–387.
Colbern, D., Isaacson, R. L., Hannigan, J. H., Jr., & Gispen, W. H. Water immersion, excessive grooming, and paper shredding in the rat. Behavioral and Neural Biology, 1981, 32, 428–437.
Cools, A. R., Wiegant, V. M., & Gispen, W. H. Distinct dopaminergic systems in ACTH-induced grooming. European Journal of Pharmacology, 1978, 50, 265–268.
Gispen, W. H., & Isaacson, R. L. ACTH-induced grooming in the rat. Pharmacology and Therapeutics, 1981, 12, 209–246.
Gispen, W. H., Ormond, D., Ten Haaf, J., & de Wied, D. Modulation of ACTH-induced grooming by [des-Tyr1]-γ-endorphin and haloperidol. European Journal of Pharmacology, 1980, 63, 203–207.
Gispen, W. H., Wiegant, V. M., Greven, H. M., & de Wied, D. The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH: Structure activity studies. Life Sciences, 1975, 17, 645–652.
Hannigan, J. H., Balaz, M. A., Springer, J. E., Ryan, J. P., & Isaacson, R. L. Hippocampal lesions: Are the secondary dopaminergic changes following the lesion responsible for the decrease in ACTH-induced excessive grooming? Neuroscience Abstracts, 1982, 8, 371.
Isaacson, R. L., & Colbern, D. Hippocampal lesions, haloperidol, and excessive grooming. Physiological Psychology, 1981, 9, 260–262.
Keppel, G. Design and analysis: A researcher’s handbook. Englewood Cliffs, N.J: Prentice-Hall, 1973.
Reinstein, D. K., Hannigan, J. H., Jr., & Isaacson, R. L. Time course of certain behavioral changes after hippocampal damage and their alteration dopaminergic intervention into nucleus accumbens. Pharmacology, Biochemistry and Behavior, 1982, 17, 193–202.
Springer, J. H., Isaacson, R. L., Ryan, J. P., & Hannigan, J. H., Jr. Dopamine depletion in nucleus accumbens reduces neuropeptide-induced excessive grooming. Life Sciences, 1983, in press.
Wiegant, V. M., Cools, A. R., & Gispen, W. H. ACTH-induced excessive grooming involves brain dopamine. European Journal of Pharmacology, 1977, 41, 343–345.
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Ryan, J.P., Isaacson, R.L. Intra-accumbens injections of ACTH induce excessive grooming in rats. Psychobiology 11, 54–58 (1983). https://doi.org/10.3758/BF03326769
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DOI: https://doi.org/10.3758/BF03326769