The Protective Effect of Curcumin against Nitrosamine-Induced Gastric Oxidative Stress in Rats

Mostafa Ibrahim Waly; Ismail M. Al-Bulushi; Shaimaa Al-Hinai; Nejib Guizani; Raya Nasser Al-Malki; Mohammad Shafiur Rahman

doi:10.3746/pnf.2018.23.4.288

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한국식품영양과학회
Preventive Nutrition and Food Science 학술저널
Preventive Nutrition and Food Science Vol.23 No.4
2018.12 288 - 293 (6page)
DOI : 10.3746/pnf.2018.23.4.288

저자정보

Mostafa Ibrahim Waly (Sultan Qaboos University)
Ismail M. Al-Bulushi (Sultan Qaboos University)
Shaimaa Al-Hinai (Sultan Qaboos University)
Nejib Guizani (Sultan Qaboos University)
Raya Nasser Al-Malki (Sultan Qaboos University)

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Curcumin has a wide spectrum of biological, pharmaceutical, and antioxidant effects in cancer experimental models. Nitrosamine is commonly used as an experimental oxidizing agent which induces gastric oxidative stress and gastric carcinogenesis in rats. We examined the antioxidant potential effect of curcumin against nitrosamine-induced gastric oxidative stress in rats. Forty Sprague-Dawley rats were randomly divided into 4 groups (10 rats/group). The control group was fed a standard diet and received a single dose of normal saline, the nitrosamine-treated group was fed a standard diet and received an intraperitoneal injection of nitrosamine at a single dose of 100 mg/kg body weight (b.w.). The other two groups received a daily dose of curcumin (200 mg/kg b.w.) via intra-gastric intubation in the presence or absence of nitrosamine injection. After 16 weeks, all rats were sacrificed, and the gastric tissues were dissected for histopathological examination and for biochemical measurements of oxidative stress indices. Our results showed that nitrosamine causes oxidative stress in gastric tissues as evidenced by glutathione depletion, increased level of lipid peroxides, nitric oxide release, impairment of total antioxidant capacity, DNA oxidative damage, and inhibition of antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase, and superoxide dismutase). Histopathological findings revealed abnormal gastric architecture in association with nitrosamine injection compared to the non-treated control group. Curcumin significantly suppressed the gastric oxidative damage associated with nitrosamine treatment and mitigated its histopathological effect. These results suggest that curcumin, as an antioxidant, has a therapeutic effect against oxidative stress-mediated gastric diseases.

#curcumin #nitrosamine #oxidative stress #gastric tissue