Objectives : The purpose of the present study was to conduct a comparison of structural brain alterations between people with Internet gaming disorder (IGD) and alcohol use disorder (AUD) in young males. Methods ： Twenty-four young males with IGD, 22 young males with AUD, and 30 healthy control (HC) subjects participated in this study. We applied voxel-based morphometric analysis with diffeomorphic anatomical registration using an exponentiated Lie algebra algorithm. A whole-brain analysis was conducted to investigate the locations of gray matter volume differences between the groups. Results ： Both the Individuals with IGD and AUD had significantly smaller gray matter volume in the left inferior parietal lobe than the healthy controls (IGD＜HC, p=0.005; AUD＜HC, p＜0.001). There was no significant difference in gray matter volume in the inferior parietal lobule between the IGD and AUD groups. Conclusion : We demonstrated that IGD and AUD shared structural abnormalities in the inferior parietal lobule. The inferior parietal lobule is involved in the integration between top-down and bottom-up control. The volume of the gray matter in the inferior parietal lobule is known to be highly influenced by genetic factors. The results of this study suggest susceptibility shared between people with IGD and those with AUD.
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