International Journal of Cardiovascular Sciences. 30/Oct/2020;34(2):124-33.

Maternal Intake of Flaxseed During Lactation and Exercise Training Protect Against Salt Overload-Induced Aortic Remodeling in Adult Offspring

Simoni Silva-Couto , André Manoel Correia-Santos , Gabriela Câmara Vicente , Caroline Luiza Codonho Castro , Vanessa de Lana Melo Barreto , Joyce Eduarda Campos Martins , Queila Lenzi , Gilson Teles Boaventura , Maurício Alves Chagas

DOI: 10.36660/ijcs.20190165

Abstract

Background

High dietary sodium intake can induce endothelial stiffness even without changes in blood pressure.

Objectives

To evaluate the effects of exercise training and chronic intake of sodium chloride solution on aortic morphology of male offspring of rat dams who consumed flaxseed during lactation.

Methods

Female rats were fed with a control diet or a flaxseed diet during lactation. At weaning, two male offspring of each rat dam were allocated into eight groups for 180 days: four groups received a control diet e four received a flaxseed diet, with /without exercise and with/without NaCl solution supply. Aorta was collected for histomorphometric analysis. The one-way analysis of variance was used and P value < 0.05 was considered statistically significant.

Results

The chronic use of 1% NaCl solution led to changes in aortic histoarchitecture in the control group: increase in aortic intima-media thickness (10,4%, p<0.0001) and reduced number of elastic lamellae (-8,1%, p<0.0001). Groups of offspring of mother that consumed flaxseed during lactation, the chronic use of 1% NaCl alone did not lead to an increase in the aortic intima-media thickness. Exercise training of adult offspring increased aortic intima-media thickness (13.3%, p<0.0001), with preservation of elastic components and aortic flexibility.

Conclusion

Chronic salt overload caused adverse effects on the aorta of rats, and maternal consumption of the flaxseed diet during lactation protected against aortic remodeling. Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0