Investigation of In Vitro Cytotoxic Effects of Montivipera xanthina on Healthy and Cancer Human Lung Cell Lines †
Department of Biology, Science and Art Faculty, Uludag University, Bursa 16059, Turkey
*
Author to whom correspondence should be addressed.
†
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Proceedings 2017, 1(10), 1029; https://doi.org/10.3390/proceedings1101029
Published: 14 November 2017
(This article belongs to the Proceedings of Proceedings of the 2nd International Conference on Natural Products for Cancer Prevention and Therapy)
Abstract
:Biotoxins have been used for therapeutic purposes in many cultures since ancient times. It is known that from simple to more complex organisms the animal kingdom contain poisons. Works in the field of anti-cancer seems to concentrate especially on bees, spiders, scorpions and snake venoms. In the present study, it was aimed to investigate the in vitro cytotoxic effects of Montivipera xanthina on normal and cancer human lung cell lines. For this purpose the cytotoxic effects of venoms collected from both species were investigated using XTT and Clonogenic assay on A549 human lung cancer and Beas-2B human healthy bronchial epithelial cell lines. In cytotoxicity tests it has been determined that venoms of M. xanthina concentration dependently decreased the viability of both A549 and Beas-2B cells. As a result of the XTT test, the IC50 values of the M. xanthina venom on A549 and Beas-2B were calculated as 1553 μg/mL and 2156 μg/mL, respectively. In the clonogenic test, these values were determined as 2112 μg/mL and 2457 μg/mL for the A549 and Beas-2B cells, respectively.
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MDPI and ACS Style
Huriyet, H.; Cavas, T.; Vatan, O.; Cinkilic, N. Investigation of In Vitro Cytotoxic Effects of Montivipera xanthina on Healthy and Cancer Human Lung Cell Lines. Proceedings 2017, 1, 1029. https://doi.org/10.3390/proceedings1101029
AMA Style
Huriyet H, Cavas T, Vatan O, Cinkilic N. Investigation of In Vitro Cytotoxic Effects of Montivipera xanthina on Healthy and Cancer Human Lung Cell Lines. Proceedings. 2017; 1(10):1029. https://doi.org/10.3390/proceedings1101029
Chicago/Turabian StyleHuriyet, Huzeyfe, Tolga Cavas, Ozgur Vatan, and Nilufer Cinkilic. 2017. "Investigation of In Vitro Cytotoxic Effects of Montivipera xanthina on Healthy and Cancer Human Lung Cell Lines" Proceedings 1, no. 10: 1029. https://doi.org/10.3390/proceedings1101029
