Plasma Modification Techniques for Natural Polymer-Based Drug Delivery Systems
Abstract
:1. Introduction
2. Plasma Generation and Process Control
3. Types of Plasma Sources
4. Control of Plasma Parameters
5. Plasma Diagnostics
6. Characterization of Plasma-Treated Natural Polymer Surfaces
6.1. Surface Chemistry Analysis
6.2. Surface Morphology Analysis
6.3. Surface Energy Analysis
6.4. Other Surface Characterization Techniques
7. Plasma Modification of Natural Polymer-Based Drug Delivery Systems
7.1. Surface Modification for Improved Biocompatibility
7.2. Surface Modification for Controlled Drug Release
7.3. Surface Modification for Targeted Drug Delivery
7.4. Surface Modification for Enhanced Cellular Uptake
8. Plasma Modification of Natural Polymer-Based Hydrogels
8.1. Surface Modification for Improved Biocompatibility
8.2. Surface Modification for Controlled Drug Release
8.3. Surface Modification for Enhanced Cellular Uptake
9. Recent Advancement in Plasma-Modified Natural Polymer-Based Drug Delivery Systems
9.1. Plasma-Modified Natural Polymer-Based Drug Delivery Systems for Cancer Therapy
9.2. Plasma-Modified Natural Polymer-Based Drug Delivery Systems for Wound Healing
9.3. Plasma-Modified Natural Polymer-Based Drug Delivery Systems for Immunotherapy
9.4. Plasma-Modified Natural Polymer-Based Drug Delivery Systems for Gene Delivery
9.5. Plasma-Modified Natural Polymer-Based Drug Delivery Systems for Vaccines
9.6. Plasma-Based 3D Printing for Fabrication of Complex Drug Delivery Systems
10. Challenges and Future Directions
10.1. Poor Bioadhesion
10.2. Inadequate Biocompatibility
10.3. Limited Drug Loading and Release Capacity
10.4. Lack of Specificity
10.5. Limited Mechanical Strength
10.6. Plasma-Modified Natural Polymer-Based Drug Delivery Systems for Cancer Therapy
10.7. Emerging Trends in Plasma Modification of Natural Polymer-Based Drug Delivery Systems
10.8. Future Prospects and Opportunities
11. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Natural Polymer-Based Drug Delivery System | Plasma Treatment | Improvement in Biocompatibility | Reference |
---|---|---|---|
Chitosan Nanoparticles | Oxygen plasma | Reduced cytotoxicity and enhanced cellular uptake of drugs | [62] |
Alginate Hydrogels | Argon plasma | Improved cell adhesion and proliferation | [63] |
Starch-Based Films | Nitrogen plasma | Improved hydrophilicity, reduced contact angle, and increased cell adhesion | [64] |
Cellulose Nanocrystals | Oxygen plasma | Improved cell proliferation and viability | [65] |
Gelatin Microspheres | Argon plasma | Improved drug loading and release | [66] |
Silk Fibroin Films | Oxygen plasma | Improved cell adhesion and proliferation | [67] |
Hyaluronic Acid Nanoparticles | Oxygen plasma | Reduced cytotoxicity and enhanced biocompatibility | [68] |
Pectin Hydrogels | Argon plasma | Improved cell adhesion and proliferation | [69] |
Low-Density Polyethylene (LLDPE) and Poly(ethylene terephthalate) (PET) Films | Plasma source ion implantation (PSII) technique | Improved surface hydrophobic properties and increased contact angle and decreased surface energy observed | [70] |
Ultra-High-Modulus Polyethylene Monofilaments | Oxygen plasma treatment | Improved adhesion to epoxy resins | [71] |
Multi-Nanolayer Anticancer Drug | Low-pressure inductively coupled plasma (ICP) | Carboplatin and various other medications remained identifiable on the membrane for a duration exceeding 14 days in an artificial environment, while in a living organism, their detectability extended beyond a period of 10 days. The presence of a cytotoxic mesh resulted in a significant reduction in cellular adherence by a factor of 5.42 and provoked a substantial increase in the destruction of cancer cells by up to 7.87 times. | [72] |
Plasma Polymerized Nanoparticles (PPNs) | Reactive gas discharges plasma treatment | PPNs carrying a combination of siVEGF and paclitaxel at reduced doses significantly reduced tumor growth in mice. | [73] |
Tartary Buckwheat Starch | High-voltage and short-time (HV-ST) dielectric barrier discharge (DBD) plasma treatment | Improved solubility, paste clarity, in vitro digestibility, and decreased amylose content and viscosity. | [74] |
PC, PP, EPDM, PE, PS, PET, and PMMA polymers | Ar, He, or N2 plasma treatments | Improved wetting, friction properties, and adhesion property. | [75] |
Application | Natural Polymer | Plasma Modification | Reference |
---|---|---|---|
Gene Delivery | Chitosan | Improved hydrophilicity and charge density | [126] |
Gene Delivery | Alginate | Increased surface area and introduction of functional groups | [127] |
Gene Delivery | Hyaluronic Acid | Increased stability in the presence of hyaluronidase | [128] |
Vaccine Delivery | Chitosan | Increased cellular uptake and immunogenicity | [129] |
Vaccine Delivery | Chitosan | Facilitation of mucosal delivery and enhanced immunogenicity | [130] |
Cancer Therapy | Chitosan | Enhanced cellular uptake and cytotoxicity | [131] |
Wound Healing | Alginate | Improved cell proliferation and angiogenesis | [132] |
Tissue Engineering | Hyaluronic Acid | Increased bioactivity and mechanical properties | [133] |
Gene Therapy | Chitosan | Enhanced transfection efficiency | [134] |
Anti-inflammatory Therapy | Gelatin | Increased drug loading and release | [135] |
Dental Materials | Chitosan | Improved antibacterial properties | [136] |
Skin Regeneration | Silk Fibroin | Improved mechanical properties and biocompatibility | [137] |
Cardiovascular Disease | Hyaluronic Acid | Improved biocompatibility | [138] |
Neurodegenerative Disease | Chondroitin Sulphate | Enhanced cell viability | [139] |
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Bhatt, P.; Kumar, V.; Subramaniyan, V.; Nagarajan, K.; Sekar, M.; Chinni, S.V.; Ramachawolran, G. Plasma Modification Techniques for Natural Polymer-Based Drug Delivery Systems. Pharmaceutics 2023, 15, 2066. https://doi.org/10.3390/pharmaceutics15082066
Bhatt P, Kumar V, Subramaniyan V, Nagarajan K, Sekar M, Chinni SV, Ramachawolran G. Plasma Modification Techniques for Natural Polymer-Based Drug Delivery Systems. Pharmaceutics. 2023; 15(8):2066. https://doi.org/10.3390/pharmaceutics15082066
Chicago/Turabian StyleBhatt, Pankaj, Vipin Kumar, Vetriselvan Subramaniyan, Kandasamy Nagarajan, Mahendran Sekar, Suresh V. Chinni, and Gobinath Ramachawolran. 2023. "Plasma Modification Techniques for Natural Polymer-Based Drug Delivery Systems" Pharmaceutics 15, no. 8: 2066. https://doi.org/10.3390/pharmaceutics15082066