The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential
Abstract
:1. Introduction
2. Characteristics of the Breast Microbiome
3. Role of the Microbiome in Obesity-Induced Inflammation
4. Microbiota and Breast Cancer
5. Etiology of Microbiome Dysbiosis in Breast Cancer
6. The Microbiome as a Biomarker and Treatment Target
7. Conclusions
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
Abbreviations
ANC | Absolute neutrophil count |
ARG1 | Arginase-1 |
β-Gluc | β-glucosidase |
β-GUS | β-glucuronidase |
CCL2 | Chemokine (C-C motif) ligand 2 (s. Monocyte chemoattractant protein-1, MCP-1) |
CRP | C-reactive protein |
F/B | Firmicutes/Bacteroidetes bacterial ratio |
FBG | Fasting blood glucose |
FMT | Fecal microbiota transplantation |
FXR | Farnesoid X receptor |
HFD | High-fat diet |
IGF | Insulin-like growth factor |
IL | Interleukin |
INF-γ | Interferon-gamma |
LAB | Lactic acid bacteria |
LDL-C | Low-density lipoprotein cholesterol |
LPS | Lipopolysaccharide |
NOS | Nitric oxide synthase |
ob/ob mice | Leptin-deficient mice |
PPARγ | Peroxisome proliferator-activated receptor gamma |
PXR | Pregnane X receptor |
SCFA | Short-chain fatty acid |
TGR5 | Takeda G-protein coupled receptor-5 |
TNBC | Triple-negative breast cancer |
TNFα | Tumor necrosis factor-alpha |
VDR | Vitamin D receptor |
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Avtanski, D.; Reddy, V.; Stojchevski, R.; Hadzi-Petrushev, N.; Mladenov, M. The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential. Pathogens 2023, 12, 1402. https://doi.org/10.3390/pathogens12121402
Avtanski D, Reddy V, Stojchevski R, Hadzi-Petrushev N, Mladenov M. The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential. Pathogens. 2023; 12(12):1402. https://doi.org/10.3390/pathogens12121402
Chicago/Turabian StyleAvtanski, Dimiter, Varun Reddy, Radoslav Stojchevski, Nikola Hadzi-Petrushev, and Mitko Mladenov. 2023. "The Microbiome in the Obesity-Breast Cancer Axis: Diagnostic and Therapeutic Potential" Pathogens 12, no. 12: 1402. https://doi.org/10.3390/pathogens12121402