Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics
Abstract
:1. Introduction
2. Prevalence and Types of PPI Modulation
3. Protein Dynamics and the Nature of Allostery
4. Types of Allosteric PPI
4.1. Re-Balance Naturally Existing Conformational Change
4.2. Modulation of Dynamics without Conformational Change
5. Practicalities of Finding and Optimising Chemical Matter
6. Directions for Future Success with Allosteric PPIs
7. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References and Notes
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Cossins, B.P.; Lawson, A.D.G. Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics. Molecules 2015, 20, 16435-16445. https://doi.org/10.3390/molecules200916435
Cossins BP, Lawson ADG. Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics. Molecules. 2015; 20(9):16435-16445. https://doi.org/10.3390/molecules200916435
Chicago/Turabian StyleCossins, Benjamin P., and Alastair D. G. Lawson. 2015. "Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics" Molecules 20, no. 9: 16435-16445. https://doi.org/10.3390/molecules200916435