Liver Remodeling on CT Examination in Patients with HCV Compensated Cirrhosis Who Achieved Sustained Virological Response after Direct-Acting Antivirals Treatment
Abstract
:1. Introduction
2. Methods
2.1. Study Design
2.2. Scanning Protocols
2.3. Data Analytic Strategy for Imaging Interpretation
2.4. Statistical Analysis
3. Results
3.1. Patients
3.2. Hepatic Veins Diameters
3.3. The Caudate-Right Lobe Ratio and Modified Caudate-Right Lobe Ratio
3.4. Huber’s Score
3.5. Liver Volume
3.6. Central Periportal Space Widening
3.7. Right Posterior Hepatic Notch Variation
3.8. Indicators of Portal Hypertension
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Variable | Pre-Treatment | Post-Treatment | p | ||
---|---|---|---|---|---|
Median | IQR | Median | IQR | ||
Liver volume (cm3) | 1786.77 | 879.23 | 1716.44 | 840.50 | 0.049 |
Caudate-right lobe ratio | 0.65 | 0.19 | 0.65 | 0.17 | ns |
Modified caudate-right lobe ratio | 0.98 | 0.28 | 0.99 | 0.31 | ns |
Right hepatic vein diameter (mm) | 6.36 | 3.94 | 8.12 | 4.20 | <0.001 |
Middle hepatic vein diameter (mm) | 5.70 | 2.48 | 5.91 | 2.51 | ns |
Left hepatic vein diameter (mm) | 6.69 | 3.17 | 6.65 | 3.19 | ns |
Sum of hepatic vein diameters (mm) | 19.29 | 9.52 | 21.44 | 9.06 | 0.028 |
Huber’s score | 19.16 | 11.50 | 20.58 | 9.73 | 0.035 |
Central periportal space widening (mm) | 11.85 | 5.75 | 11.7 | 6.47 | ns |
Right posterior hepatic notch (degrees) | 126.3 | 26.05 | 136.9 | 17.30 | ns |
Splenic volume (cm3) | 564.79 | 342.54 | 474.45 | 330.00 | 0.012 |
Portal trunk diameter (mm) | 14 | 2.70 | 14.2 | 2.90 | ns |
Superior mesenteric vein diameter (mm) | 12.7 | 2.90 | 12.2 | 2.70 | ns |
Splenic vein diameter (mm) | 9.85 | 3.31 | 10.2 | 3.73 | ns |
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Mihai, F.; Trifan, A.; Stanciu, C.; Singeap, A.M.; Cucuteanu, B.; Lupascu Ursulescu, C.; Pop, C.; Girleanu, I.; Cuciureanu, T.; Negru, D.; et al. Liver Remodeling on CT Examination in Patients with HCV Compensated Cirrhosis Who Achieved Sustained Virological Response after Direct-Acting Antivirals Treatment. Medicina 2020, 56, 171. https://doi.org/10.3390/medicina56040171
Mihai F, Trifan A, Stanciu C, Singeap AM, Cucuteanu B, Lupascu Ursulescu C, Pop C, Girleanu I, Cuciureanu T, Negru D, et al. Liver Remodeling on CT Examination in Patients with HCV Compensated Cirrhosis Who Achieved Sustained Virological Response after Direct-Acting Antivirals Treatment. Medicina. 2020; 56(4):171. https://doi.org/10.3390/medicina56040171
Chicago/Turabian StyleMihai, Florin, Anca Trifan, Carol Stanciu, Ana Maria Singeap, Bogdan Cucuteanu, Corina Lupascu Ursulescu, Corina Pop, Irina Girleanu, Tudor Cuciureanu, Dragos Negru, and et al. 2020. "Liver Remodeling on CT Examination in Patients with HCV Compensated Cirrhosis Who Achieved Sustained Virological Response after Direct-Acting Antivirals Treatment" Medicina 56, no. 4: 171. https://doi.org/10.3390/medicina56040171