Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Immunohistochemical Staining of KLF17
2.3. Patient and Public Involvement
2.4. Statistical Analyses
3. Results
3.1. High KLF17 Expression Levels are More Likely in Early-Stage and Low T-Value Patients with OSCC
3.2. Patients with OSCC with Advanced Stage or Low KLF17 Expression Had a Poor Clinical Outcome
3.3. KLF17 Expression Level as a Prognostic Tool According to Clinicopathological Characteristics of OSCC
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Parameters | Case Number | KLF17 Expression | p-Value | |
---|---|---|---|---|
Low | High | |||
Age (year) | 56.7 ± 10.7 | 56.3 ± 12.1 | 0.782 | |
Gender | ||||
Female | 45 | 16 (35.6) | 29 (64.4) | 0.028 |
Male | 238 | 127 (53.4) | 111 (46.6) | |
Smoking | ||||
No | 162 | 81 (50.0) | 81 (50.0) | 0.837 |
Yes | 121 | 62 (51.2) | 59 (48.8) | |
Betel quid chewing | ||||
No | 228 | 118 (51.8) | 110 (48.2) | 0.402 |
Yes | 55 | 25 (45.5) | 30 (54.5) | |
Differentiation | ||||
Well | 40 | 15 (37.5) | 25 (62.5) | 0.075 |
Moderate + Poor | 243 | 128 (52.7) | 115 (47.3) | |
Stage | ||||
I | 60 | 23 (38.3) | 37 (61.7) | 0.033 |
II + III + IV | 223 | 120 (53.8) | 103 (46.2) | |
T-value | ||||
1 | 79 | 32 (40.5) | 47 (59.5) | 0.036 |
2 + 3 + 4 | 204 | 111 (54.4) | 93 (45.6) | |
N-value | ||||
0 | 173 | 89 (51.4) | 84 (48.6) | 0.699 |
1 + 2 + 3 | 110 | 54 (49.1) | 56 (50.9) |
Parameter | Category | Overall Survival | |||
---|---|---|---|---|---|
5-year Survival (%) | HR | 95% CI | p-Value | ||
Age | ≥57/<57 | 60.5/57.3 | 0.992 | 0.689–1.428 | 0.966 |
Gender | Male/Female | 56.6/62.6 | 1.277 | 0.731–2.232 | 0.391 |
Smoking | Yes/No | 58.9/56.4 | 0.919 | 0.638–1.325 | 0.653 |
Betel quid chewing | Yes/No | 56.7/59.4 | 0.819 | 0.596–1.326 | 0.417 |
Stage | II + III + IV/I | 54.1/70.4 | 1.775 | 1.062–2.968 | 0.029 |
KLF17 | Low/High | 49.6/66.5 | 1.614 | 1.114–2.336 | 0.011 |
Parameter | Category | Overall Survival | |||
---|---|---|---|---|---|
Mean Survival (years) | HR | 95% CI | p-Value | ||
Age | ≥57/<57 | 4.7/4.7 | 0.926 | 0.637–1.347 | 0.689 |
Gender | Male/Female | 4.6/5.0 | 1.171 | 0.651–2.106 | 0.598 |
Smoking | Yes/No | 4.8/4.6 | 0.894 | 0.580–1.378 | 0.612 |
Betel quid chewing | Yes/No | 5.0/4.6 | 0.826 | 0.470–1.450 | 0.505 |
Stage | II + III + IV/I | 4.5/5.4 | 1.738 | 1.024–2.951 | 0.041 |
KLF17 | Low/High | 4.3/5.1 | 1.506 | 1.034–2.191 | 0.033 |
Parameter | Overall Survival 1 | |||
---|---|---|---|---|
5-year Survival (%) 2 | HR | 95% CI | p-Value | |
All cases 2 | 49.6/66.5 | 1.506 | 1.034–2.191 | 0.033 |
Age (year) | ||||
<57 | 50.3/64.8 | 1.351 | 0.828–2.206 | 0.229 |
≥57 | 49.2/69.0 | 1.619 | 0.896–2.926 | 0.110 |
Gender | ||||
Female | 50.6/72.2 | 1.512 | 0.520–4.394 | 0.447 |
Male | 49.4/65.5 | 1.475 | 0.987–2.203 | 0.058 |
Smoking | ||||
No | 49.0/65.1 | 1.341 | 0.817–2.201 | 0.245 |
Yes | 50.4/68.2 | 1.701 | 0.951–3.041 | 0.073 |
Betel quid chewing | ||||
No | 52.0/62.3 | 1.258 | 0.839–1.888 | 0.267 |
Yes 2 | 38.2/79.4 | 2.934 | 1.043–8.249 | 0.041 |
Differentiation | ||||
Well | 64.6/76.2 | 1.151 | 0.267–4.967 | 0.851 |
Moderate + Poor 3 | 47.9/64.2 | 1.547 | 1.035–2.311 | 0.033 |
Stage | ||||
I | 60.6/77.4 | 1.397 | 0.522–3.736 | 0.506 |
II + III + IV | 47.5/62.5 | 1.440 | 0.958–2.164 | 0.080 |
T-value | ||||
1 | 52.9/78.1 | 2.471 | 1.076–5.673 | 0.033 |
2 + 3 + 4 | 48.5/60.4 | 1.307 | 0.856–1.995 | 0.214 |
N-value | ||||
0 | 61.6/75.9 | 1.652 | 0.933–2.926 | 0.085 |
1 + 2 + 3 | 29.8/51.3 | 1.589 | 0.952–2.652 | 0.076 |
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Lee, Y.-J.; Chan, L.; Yeh, C.-M.; Lee, C.-H.; Sung, W.-W. Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study. Medicina 2020, 56, 57. https://doi.org/10.3390/medicina56020057
Lee Y-J, Chan L, Yeh C-M, Lee C-H, Sung W-W. Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study. Medicina. 2020; 56(2):57. https://doi.org/10.3390/medicina56020057
Chicago/Turabian StyleLee, Yi-Ju, Lung Chan, Chung-Min Yeh, Chien-Hsun Lee, and Wen-Wei Sung. 2020. "Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study" Medicina 56, no. 2: 57. https://doi.org/10.3390/medicina56020057