The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS
Abstract
:1. Introduction
2. Mitochondrial Dysfunction at the Core of ALS Pathophysiology
3. Glia, Neuroinflammation and Motor Neuron Mitochondria
4. Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Mechanisms Leading to the Death of Motor Neurons
4.1. Oxidative Stress, Redox Status and Mitochondria
4.2. Bioenergetics and Mitochondria
5. Targeting Mitochondria as a Therapy
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
References
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Obrador, E.; Salvador-Palmer, R.; López-Blanch, R.; Jihad-Jebbar, A.; Vallés, S.L.; Estrela, J.M. The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS. Int. J. Mol. Sci. 2021, 22, 6352. https://doi.org/10.3390/ijms22126352
Obrador E, Salvador-Palmer R, López-Blanch R, Jihad-Jebbar A, Vallés SL, Estrela JM. The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS. International Journal of Molecular Sciences. 2021; 22(12):6352. https://doi.org/10.3390/ijms22126352
Chicago/Turabian StyleObrador, Elena, Rosario Salvador-Palmer, Rafael López-Blanch, Ali Jihad-Jebbar, Soraya L. Vallés, and José M. Estrela. 2021. "The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS" International Journal of Molecular Sciences 22, no. 12: 6352. https://doi.org/10.3390/ijms22126352