Synergistic Efficacy of Plaque Control with Intralesional Triamcinolone Acetonide Injection on Erosive Non-Gingival Oral Lichen Planus: A Randomized Controlled Clinical Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Randomization
2.3. Study Interventions
2.4. Clinical Assessment
2.5. Adverse Reactions
2.6. Blind Evaluation
2.7. Follow-Up Assessment
2.8. Statistical Analysis
3. Results
3.1. Participants
3.2. Baseline
3.3. Efficacy Analysis
3.4. Improvement of Periodontal Status
3.5. Recurrence Analysis
3.6. Safety Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Experimental Group (n = 25) | Control Group (n = 23) | p Value | |
---|---|---|---|
Age, year (mean ± SD) | 46.5 ± 9.9 | 49 ± 11.4 | 0.42 |
Sex, number (%) | 0.68 | ||
Male | 9 (36.0%) | 7 (30.4%) | |
Female | 16 (64.0%) | 16 (69.6%) | |
Position, number (%) | 1 | ||
Buccal | 23 (92.0%) | 21 (91.3%) | |
Ventral of the tongue | 2 (8.0%) | 2 (8.7%) | |
OLP duration, month (mean ± SD) | 26.2 ± 15.8 | 31.1 ± 18.9 | 0.33 |
Group | Completely Healed (%) | Not Completely Healed (%) | Total |
---|---|---|---|
E | 23 (95.8%) | 1 (4.2%) | 24 |
C | 16 (69.6%) | 7 (30.4%) | 23 |
Total | 39 | 8 | 47 |
Group | Number | Mean | SD | bp Value | c Cohen’s d (95% CI) | |
---|---|---|---|---|---|---|
Erosion size (mm2) | ||||||
First visit | E | 25 | 22.3 | 20.4 | 0.40 | |
C | 23 | 16.0 | 12.4 | |||
a Reduced erosion area at day 14 ± 2 | E | 24 | 19.1 | 12.8 | 0.029 * | 0.68 (0.08, 1.28) |
C | 23 | 10.3 | 13.2 | |||
NRS score | ||||||
First visit | E | 25 | 4.3 | 1.8 | 0.29 | |
C | 23 | 4.9 | 1.7 | |||
a Reduced NRS at day 14 ± 2 | E | 24 | 3.9 | 1.7 | 0.036 * | 0.63 (0.03, 1.23) |
C | 23 | 2.6 | 2.4 | |||
PI | ||||||
First visit | E | 25 | 2.6 | 1.3 | 0.95 | |
C | 23 | 2.5 | 0.9 | |||
a Reduced PI at day 14 ± 2 | E | 24 | 1.7 | 0.9 | <0.001 *** | 1.29 (0.65, 1.93) |
C | 23 | 0.6 | 0.8 | |||
CPI | ||||||
First visit | E | 25 | 2.0 | 0.8 | 0.10 | |
C | 23 | 2.4 | 0.7 | |||
a Reduced CPI at day 14 ± 2 | E | 24 | 1.6 | 0.9 | <0.001 *** | 1.36 (0.71, 2.01) |
C | 23 | 0.5 | 0.7 |
Group | Not Recurred (%) | b Recurred (%) | Total |
---|---|---|---|
E | 15 (68.2%) | 7 (31.8%) | 22 |
C | 10 (62.5%) | 6 (37.5%) | 16 |
Total | 26 | 12 | 38 |
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Zhao, W.; Lin, D.; Deng, S.; Wang, S.; Guo, Y.; Yang, J.; Shi, X.; Zhou, H. Synergistic Efficacy of Plaque Control with Intralesional Triamcinolone Acetonide Injection on Erosive Non-Gingival Oral Lichen Planus: A Randomized Controlled Clinical Trial. Int. J. Environ. Res. Public Health 2022, 19, 13787. https://doi.org/10.3390/ijerph192113787
Zhao W, Lin D, Deng S, Wang S, Guo Y, Yang J, Shi X, Zhou H. Synergistic Efficacy of Plaque Control with Intralesional Triamcinolone Acetonide Injection on Erosive Non-Gingival Oral Lichen Planus: A Randomized Controlled Clinical Trial. International Journal of Environmental Research and Public Health. 2022; 19(21):13787. https://doi.org/10.3390/ijerph192113787
Chicago/Turabian StyleZhao, Wei, Duanxian Lin, Shuzhi Deng, Shimeng Wang, Yiqing Guo, Jin Yang, Xueke Shi, and Hongmei Zhou. 2022. "Synergistic Efficacy of Plaque Control with Intralesional Triamcinolone Acetonide Injection on Erosive Non-Gingival Oral Lichen Planus: A Randomized Controlled Clinical Trial" International Journal of Environmental Research and Public Health 19, no. 21: 13787. https://doi.org/10.3390/ijerph192113787