Short Peptides for Hydrolase Supramolecular Mimicry and Their Potential Applications
Abstract
:1. Introduction
2. Hydrolase Classification
3. Hydrolase Applications
- Low-cost;
- Robust;
- Tolerant to organic solvents;
- Promiscuous towards the catalysis of a variety of reactions.
3.1. Chemical Synthesis
3.2. Medicinal Uses
3.3. Food Industry
3.4. Beverage Industry
3.5. Cosmetic Uses and Personal Care Products
3.6. Paper Industry
3.7. Leather, Wool, Fur, and Textile Industry
3.8. Environmental Remediation
3.9. Biosensing
3.10. Biodiesel Production
4. Hydrolase Supramolecular Mimicry by Self-Assembling Peptides
5. Multifunctional Supramolecular Biocatalysts Based on Hydrolytic Peptides
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Peptide Sequence | Assembly Type | Reaction Conditions | Substrate | Catalytic Efficiency 1 | Refs. |
---|---|---|---|---|---|
Ac-CFEFSFHFP-NH2 | Aggregates Fibrils | pH 7, 25 °C | p-NPA 2 | ε = 0.19 M−1 s−1 | [89] |
Ac-CFHFEFSFP-NH2 | Aggregates Fibrils | pH 7, 25 °C | p-NPA 2 | ε = 7.59 · 10−2 M−1 s−1 | [89] |
Ac-CFEFHFSFP-NH2 | Aggregates Fibrils | pH 7, 25 °C | p-NPA 2 | ε = 4.08 · 10−2 M−1 s−1 | [89] |
HLlIHLlI | Fibrils Hydrogel | pH 7, 25 °C | p-NPA 2 | ε = 2.9 M−1 s−1 | [90] |
Cyclo(HF) + Cyclo(CL) | Fibrils Hydrogel | pH 7, 25 °C | p-NPA 2 | ε = 0.2 M−1 s−1 | [91] |
Cyclo(HF) + Cyclo(CF) | Fibrils Hydrogel | pH 7, 25 °C | p-NPA 2 | ε = 0.09 M−1 s−1 | [91] |
Im-KLVFFAL-NH2 3 | Nanotubes | pH 7, 25 °C | p-NPOP 4 | ε = 2.1 M−1 s−1 | [92] |
Im-KLVFFAL-NH2 3 | Nanotubes | pH 7, 25 °C | p-NPP 5 | ε = 3.6 M−1 s−1 | [92] |
Im-RLVFFAL-NH2 3 | Nanotubes | pH 7, 25 °C | p-NPOP 4 | ε = 0.5 M−1 s−1 | [92] |
Im-RLVFFAL-NH2 3 | Nanotubes | pH 7, 25 °C | p-NPP 5 | ε = 1.8 M−1 s−1 | [92] |
Fmoc-VFFAHH | Nanofibers | pH 7, 25 °C | p-NPA 2 | ε = 1.0 M−1 s−1 | [93] |
Fmoc-VFFAHH | Twisted bundles | pH 7, 25 °C | p-NPA 2 | ε = 1.71 M−1 s−1 | [93] |
Cou-VFFAHH 6 | Nanofibers | pH 7, 25 °C | p-NPA 2 | ε = 0.575 M−1 s−1 | [93] |
Fmoc-FFH | MIP 7 | pH 8, 25 °C | p-NPA 2 | ε = 15.5· 10−3 mM−1 min−1 | [94] |
Fmoc-FFH | MIP 7 | pH 8, 25 °C | p-NPB 8 | ε = 11.2· 10−3 mM−1 min−1 | [94] |
Fmoc-FFH | MIP 7 | pH 8, 25 °C | p-NPH 9 | ε = 5.65· 10−3 mM−1 min−1 | [94] |
SAFHAFA 10 | Fibrils | pH 7, 37 °C | p-NPA 2 | ε = 1.07 M−1 s−1 | [95] |
HAFSAFA 10 | Fibrils | pH 7, 37 °C | p-NPA 2 | ε = 0.90 M−1 s−1 | [95] |
SAFHAFA 10 | Fibrils | pH 7, 37 °C | p-NPp 11 | ε = 0.70 M−1 s−1 | [95] |
HAFSAFA 10 | Fibrils | pH 7, 37 °C | p-NPp 11 | ε = 0.28 M−1 s−1 | [95] |
F-Zn(II) | Crystals | pH 7, 25 °C | p-NPA 2 | ε = 76.5 M−1 s−1 | [96] |
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Alletto, P.; Garcia, A.M.; Marchesan, S. Short Peptides for Hydrolase Supramolecular Mimicry and Their Potential Applications. Gels 2023, 9, 678. https://doi.org/10.3390/gels9090678
Alletto P, Garcia AM, Marchesan S. Short Peptides for Hydrolase Supramolecular Mimicry and Their Potential Applications. Gels. 2023; 9(9):678. https://doi.org/10.3390/gels9090678
Chicago/Turabian StyleAlletto, Paola, Ana Maria Garcia, and Silvia Marchesan. 2023. "Short Peptides for Hydrolase Supramolecular Mimicry and Their Potential Applications" Gels 9, no. 9: 678. https://doi.org/10.3390/gels9090678